{"id":"W1973885230","doi":"10.1016/j.bmcl.2010.06.130","title":"Structure–activity studies on acetylcholinesterase inhibition in the lycorine series of Amaryllidaceae alkaloids","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":68,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; McMaster University","keywords":"Lycorine; Amaryllidaceae Alkaloids; Chemistry; Amaryllidaceae; Pharmacophore; Acetylcholinesterase; Alkaloid; Stereochemistry; Silylation; Enzyme; Biochemistry; Biology; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002560274,0.0002898086,0.000391075,0.0003875105,0.0001674486,0.0001848684,0.0003655363,0.0002579661,0.001419325],"category_scores_gemma":[0.0003553792,0.0001649654,0.000343167,0.0002801266,0.0002043305,0.0002069625,0.0001937938,0.0004351935,0.0002708347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001592564,"about_ca_system_score_gemma":0.0001399304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001333192,"about_ca_topic_score_gemma":0.00232366,"domain_scores_codex":[0.999862,0.00004338389,0.00001691827,0.00001662956,0.00003086646,0.00003017871],"domain_scores_gemma":[0.9997692,0.00007650231,0.00004421749,0.00001945322,0.00005143122,0.00003921912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001546892,0.0003146437,0.0008080395,0.000202564,0.00005139205,0.0001567025,0.00009623723,0.0006182204,0.986809,0.0001572753,0.0001092659,0.009129659],"study_design_scores_gemma":[0.0005350622,0.01783281,0.01987273,0.00004704483,0.0002513823,0.0005259376,0.00009252812,0.002550678,0.9528984,0.00009721189,0.005264257,0.00003196878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917514,0.005297583,0.0004281518,0.0000646591,0.00001846852,0.00004085344,0.0002269924,0.00002280956,0.002149247],"genre_scores_gemma":[0.9949215,0.002946095,0.0004385645,0.00004553314,0.00001946638,0.00001795624,0.0003847795,0.000006437699,0.001219711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001419325,"threshold_uncertainty_score":0.004748166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01461106735874129,"score_gpt":0.250160197396493,"score_spread":0.2355491300377517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}