{"id":"W1973971953","doi":"10.1016/j.bpj.2010.12.2191","title":"Mode Shift of the Voltage Sensors in Shaker K+ Channels is Caused by Energetic Coupling to the Pore Domain","year":2011,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Gating; Shaker; Depolarization; Coupling (piping); Chemistry; Membrane potential; Conformational change; Biophysics; Voltage; Ion; Ion channel; Chemical physics; Molecular physics; Materials science; Physics; Vibration; Acoustics; Stereochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001950524,0.0001623023,0.0001712888,0.0001573302,0.0002536055,0.0002815438,0.0003228053,0.0003216061,0.00262647],"category_scores_gemma":[0.0004109504,0.0002159787,0.0001737582,0.00008214219,0.0004903783,0.000438004,0.0003431874,0.0007323208,0.0004473244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002496187,"about_ca_system_score_gemma":0.0001178241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001431325,"about_ca_topic_score_gemma":0.0002646728,"domain_scores_codex":[0.9999313,0.00001146607,0.000005026936,0.00001864519,0.00002121876,0.00001234114],"domain_scores_gemma":[0.9997372,0.00009005234,0.00003916042,0.00004115076,0.00002910155,0.00006327888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001964717,0.00001601763,0.0002941151,0.000009544091,0.00000346354,0.00004387557,0.0000254941,0.00009340886,0.997635,0.0005912724,0.00003573876,0.001055603],"study_design_scores_gemma":[0.00007235817,0.0002988111,0.02938946,0.000009948038,0.00001572155,0.0009027825,0.0001040566,0.007213535,0.9590785,0.002202456,0.0006815489,0.00003079169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962398,0.0001092806,0.00278315,0.00007664572,0.00001896335,0.000004472025,0.00004023257,0.00004343152,0.0006839478],"genre_scores_gemma":[0.999024,0.00004358273,0.0004732063,0.00003862144,0.000005719444,0.000005363608,0.00003761569,0.00001494483,0.0003569107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00262647,"threshold_uncertainty_score":0.00878644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01509444437008328,"score_gpt":0.2355808474381856,"score_spread":0.2204864030681023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}