{"id":"W1973972095","doi":"10.1002/(sici)1097-0290(20000220)67:4<435::aid-bit7>3.0.co;2-y","title":"Understanding factors that limit the productivity of suspension-based perfusion cultures operated at high medium renewal rates","year":2000,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institut National de la Recherche Scientifique","funders":"","keywords":"Sparging; Bioreactor; Glutamine; Perfusion; Chemistry; Air sparging; Chemostat; Chromatography; Biochemistry; Animal science; Biology; Internal medicine; Contamination; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001043649,0.0005873495,0.0006215261,0.0002567397,0.0002304408,0.001980457,0.0006745713,0.0006658473,0.0005094825],"category_scores_gemma":[0.001846244,0.0002770236,0.0004124431,0.0003694616,0.0002964875,0.001259776,0.0005039234,0.0008918713,0.0003696287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007818606,"about_ca_system_score_gemma":0.0004147204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001987393,"about_ca_topic_score_gemma":0.001604381,"domain_scores_codex":[0.99933,0.00009643118,0.00008050221,0.0001352284,0.0002242656,0.0001334518],"domain_scores_gemma":[0.9986149,0.0006815314,0.0003316776,0.00007290187,0.0002251164,0.00007383603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006521586,0.00002728966,0.002075688,0.00008599312,0.000009259849,0.00005318532,0.00003116366,0.0006238542,0.994503,0.0000451909,0.00004159947,0.002438648],"study_design_scores_gemma":[0.000006443589,0.0003874608,0.01445881,0.0000260034,0.00004187275,0.0001481809,0.000183535,0.007113251,0.9762373,0.000129227,0.001251382,0.00001649241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98368,0.002815683,0.01186643,0.0002437112,0.00003650248,0.00005271539,0.0004566986,0.000102204,0.0007461147],"genre_scores_gemma":[0.9857593,0.002926976,0.00958187,0.000147471,0.00002342357,0.00007922337,0.0007619343,0.00004810102,0.0006718274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001987393,"threshold_uncertainty_score":0.005672872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02462337966603408,"score_gpt":0.2352142350735069,"score_spread":0.2105908554074728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}