{"id":"W1974003181","doi":"10.1371/journal.pone.0022019","title":"Measuring Enzymatic HIV-1 Susceptibility to Two Reverse Transcriptase Inhibitors as a Rapid and Simple Approach to HIV-1 Drug-Resistance Testing","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver","funders":"National Institute of Allergy and Infectious Diseases; Centers for Disease Control and Prevention","keywords":"Nevirapine; Emtricitabine; Lamivudine; Resistance mutation; Drug resistance; Virology; Efavirenz; Reverse-transcriptase inhibitor; Reverse transcriptase; HIV drug resistance; Drug; Multiplex; Abacavir; Pharmacology; Viral load; Medicine; Biology; Human immunodeficiency virus (HIV); Antiretroviral therapy; Polymerase chain reaction; Virus; Microbiology; Bioinformatics; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001588762,0.001363443,0.0009965389,0.001783003,0.000279076,0.0009895539,0.001064434,0.0009505294,0.001001791],"category_scores_gemma":[0.001822494,0.0004849134,0.0005897086,0.0008261313,0.0005913808,0.000542257,0.001076946,0.001359995,0.0008441645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000296362,"about_ca_system_score_gemma":0.0003312432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005400345,"about_ca_topic_score_gemma":0.0009054776,"domain_scores_codex":[0.9964689,0.0009814303,0.0001876436,0.0005354305,0.001624971,0.0002015435],"domain_scores_gemma":[0.99841,0.0007598961,0.0003335983,0.0001584911,0.0002236655,0.0001142911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001802438,0.0002955427,0.007748091,0.0001673729,0.00006732361,0.00006902091,0.00006658021,0.0009932971,0.9611501,0.0002547089,0.0002492503,0.02875855],"study_design_scores_gemma":[0.00002802267,0.00110381,0.01995139,0.00002496965,0.00009757731,0.0007522876,0.00003312914,0.01382838,0.9616756,0.0002960065,0.002130616,0.00007827632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5833495,0.005349267,0.3987526,0.0003387964,0.0002287705,0.001463334,0.003314778,0.002532165,0.004670831],"genre_scores_gemma":[0.6474891,0.002282922,0.3425474,0.0002789843,0.0001378649,0.0009789485,0.002584334,0.00009635906,0.003604115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001783003,"threshold_uncertainty_score":0.008402288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1026228233195902,"score_gpt":0.2387472360459304,"score_spread":0.1361244127263402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}