{"id":"W1974005002","doi":"10.1261/rna.045302.114","title":"Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1","year":2014,"lang":"en","type":"article","venue":"RNA","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Biology; Gene silencing; microRNA; Genetics; Gene; Computational biology; RNA interference; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000164083,0.0001382418,0.0001274603,0.00006213893,0.0001004451,0.00002173127,0.0001396473,0.0001092382,0.00001941179],"category_scores_gemma":[0.0001353968,0.0001412996,0.00006917297,0.0001016431,0.00001890507,0.000002780173,0.00008591203,0.00004523225,0.0001151789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003316611,"about_ca_system_score_gemma":0.00001697377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002075595,"about_ca_topic_score_gemma":0.00001103085,"domain_scores_codex":[0.999112,0.00007373304,0.0001459079,0.000314196,0.000113838,0.0002403597],"domain_scores_gemma":[0.9994173,0.00001820936,0.00006370746,0.0003180625,0.00003956722,0.0001431352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001002278,0.00002032928,0.0004872758,0.00003085331,0.00002602325,0.000002065424,0.00003307719,0.00008380067,0.9962803,0.000004931602,0.001007888,0.002013412],"study_design_scores_gemma":[0.0002547965,0.0001180129,0.01065877,0.00003333742,0.00002004111,0.000002728333,0.000002891769,0.0001659505,0.9857414,0.00001487579,0.0028002,0.0001870016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996246,0.000182165,0.002096654,0.00003524433,0.0001765527,0.0001960438,0.000007099657,0.00003457192,0.001025627],"genre_scores_gemma":[0.9984598,0.000004781398,0.0004921815,0.0002053108,0.0003794054,0.00002047156,0.0001519128,0.00003114821,0.0002549944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01053892,"threshold_uncertainty_score":0.5762031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005183804070347825,"score_gpt":0.2334141960530753,"score_spread":0.2282303919827274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}