{"id":"W1974046893","doi":"10.1038/leu.2012.196","title":"Ex vivo expansion of normal and chronic myeloid leukemic stem cells without functional alteration using a NUP98HOXA10homeodomain fusion gene","year":2012,"lang":"en","type":"article","venue":"Leukemia","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; BC Cancer Agency","funders":"National Cancer Institute; BC Cancer Agency; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fondation de France; Terry Fox Foundation","keywords":"Stem cell; Haematopoiesis; Biology; Myeloid leukemia; Myeloid; Cancer research; CD34; Hematopoietic stem cell; Cell biology; Ex vivo; Leukemia; Fusion gene; Cord blood; Immunology; In vivo; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001761951,0.0002409122,0.0001508845,0.0001714517,0.00008566384,0.0001849167,0.0001603887,0.0001664352,0.001502019],"category_scores_gemma":[0.00006865077,0.00008377382,0.0001181245,0.0001020388,0.0001677821,0.0001436252,0.000239989,0.0004083591,0.000329073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001499791,"about_ca_system_score_gemma":0.0001192769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001947806,"about_ca_topic_score_gemma":0.00045588,"domain_scores_codex":[0.9998578,0.00002013539,0.00001998865,0.00002972284,0.00004736082,0.00002500657],"domain_scores_gemma":[0.9998889,0.00002497896,0.00002614707,0.00001779655,0.00000650162,0.00003563187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004551576,0.00003417196,0.0001126073,0.000009434203,0.000001004531,0.00001643902,0.000008711019,0.00001972445,0.9989107,0.00006780258,0.00001693925,0.0007570449],"study_design_scores_gemma":[0.00001419933,0.0003553175,0.00212791,0.000002170085,0.000005098773,0.0001522261,0.000008559245,0.0004380731,0.9946523,0.00001502648,0.002227545,0.000001570725],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931095,0.0004439242,0.003920206,0.00003472961,0.00001791598,0.00006429005,0.0004512882,0.00009004653,0.001868155],"genre_scores_gemma":[0.9896819,0.0002942258,0.005494589,0.00002900406,0.00000896955,0.0000822967,0.0008216421,0.00002930755,0.003557967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001502019,"threshold_uncertainty_score":0.005024731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02291217344348628,"score_gpt":0.2528970551683299,"score_spread":0.2299848817248437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}