{"id":"W1974050574","doi":"10.1097/jto.0b013e31823f459c","title":"Phase I/II Trial of Custirsen (OGX-011), an Inhibitor of Clusterin, in Combination with a Gemcitabine and Platinum Regimen in Patients with Previously Untreated Advanced Non-small Cell Lung Cancer","year":2011,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":false,"ca_institutions":"Royal Victoria Regional Health Centre; Sunnybrook Health Science Centre; Centre hospitalier de l'Université Laval; Ottawa Regional Cancer Foundation; Baker Hughes (Canada); Thames Valley Children's Centre; Ottawa Hospital; BC Cancer Agency","funders":"","keywords":"Medicine; Gemcitabine; Internal medicine; Clinical endpoint; Regimen; Carboplatin; Lung cancer; Gastroenterology; Phases of clinical research; Oncology; Population; Chemotherapy; Cisplatin; Surgery; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001425766,0.001974358,0.002676395,0.0005109994,0.0005572466,0.00148016,0.001155714,0.00144075,0.00463481],"category_scores_gemma":[0.0008677891,0.0008379283,0.001498658,0.0005859673,0.001684478,0.001101298,0.0004298224,0.004733652,0.001166274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001228338,"about_ca_system_score_gemma":0.001846342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002806334,"about_ca_topic_score_gemma":0.008290571,"domain_scores_codex":[0.9996896,0.0001259726,0.00001149996,0.00006166312,0.00002181346,0.00008961773],"domain_scores_gemma":[0.9993193,0.0001016185,0.00007786848,0.00005297948,0.00002623075,0.0004220138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8384989,0.05002324,0.003760085,0.0008333647,0.001393311,0.0002852776,0.0004118133,0.003827155,0.02226744,0.0005697032,0.007481041,0.0706486],"study_design_scores_gemma":[0.760209,0.2275647,0.005838796,0.00003242577,0.0004108455,0.0002070583,0.0001071958,0.001284615,0.001641885,0.0002600139,0.002413293,0.00003001474],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893881,0.002462569,0.0004188943,0.001025066,0.0003742721,0.001726964,0.001304401,0.0001680406,0.003131767],"genre_scores_gemma":[0.982701,0.003023971,0.001255831,0.001052293,0.0002368089,0.001753223,0.003625618,0.00005822798,0.006293197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00463481,"threshold_uncertainty_score":0.01550496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0167199706195751,"score_gpt":0.3516007821071582,"score_spread":0.3348808114875831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}