{"id":"W1974050574","doi":"10.1097/jto.0b013e31823f459c","title":"Phase I/II Trial of Custirsen (OGX-011), an Inhibitor of Clusterin, in Combination with a Gemcitabine and Platinum Regimen in Patients with Previously Untreated Advanced Non-small Cell Lung Cancer","year":2011,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":false,"ca_institutions":"Royal Victoria Regional Health Centre; Sunnybrook Health Science Centre; Centre hospitalier de l'Université Laval; Ottawa Regional Cancer Foundation; Baker Hughes (Canada); Thames Valley Children's Centre; Ottawa Hospital; BC Cancer Agency","funders":"","keywords":"Medicine; Gemcitabine; Internal medicine; Clinical endpoint; Regimen; Carboplatin; Lung cancer; Gastroenterology; Phases of clinical research; Oncology; Population; Chemotherapy; Cisplatin; Surgery; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005173394,0.00020182,0.001018426,0.0005176728,0.00002007994,0.000002602174,0.0001187928,0.0001810163,0.00004111189],"category_scores_gemma":[0.00008843691,0.0001497931,0.00004493299,0.0002975024,0.0001704386,0.0001929469,0.00007828136,0.0003292172,1.502361e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002896034,"about_ca_system_score_gemma":0.0004996345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001039519,"about_ca_topic_score_gemma":0.0004788148,"domain_scores_codex":[0.9980152,0.0002702701,0.0009925282,0.0002334071,0.0002371672,0.0002514568],"domain_scores_gemma":[0.9976335,0.00008803337,0.001416747,0.0002248457,0.0004700424,0.0001668423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6291787,0.0186239,0.3071982,0.0008536305,0.0001335236,0.0005187269,0.008325843,0.0001358398,0.004357134,0.000002090334,0.00003935819,0.03063311],"study_design_scores_gemma":[0.4557531,0.2070393,0.3241241,0.002186985,0.001049676,0.0002093341,0.001100786,0.001024305,0.007114487,0.00003176739,0.00004016748,0.0003259869],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977351,0.0001389699,0.00007615083,0.0001089049,0.0001784048,0.001486526,0.00001642818,0.000005500464,0.0002540516],"genre_scores_gemma":[0.99463,0.00004364003,0.005104758,0.00003700485,0.0000556755,0.0000383728,0.00001430621,0.00002878209,0.00004750596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1884154,"threshold_uncertainty_score":0.6108387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0167199706195751,"score_gpt":0.3516007821071582,"score_spread":0.3348808114875831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}