{"id":"W1974068770","doi":"10.1006/rtph.2001.1493","title":"IPCS Conceptual Framework for Evaluating a Mode of Action for Chemical Carcinogenesis","year":2001,"lang":"en","type":"article","venue":"Regulatory Toxicology and Pharmacology","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":348,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Canada","funders":"","keywords":"Harmonization; Risk assessment; Risk analysis (engineering); Terminology; Standardization; Computer science; Flexibility (engineering); Conceptual framework; Action (physics); Hazard; Management science; Medicine; Engineering; Chemistry; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002743134,0.0001650218,0.00029076,0.00004878484,0.0001230412,0.00000387613,0.0001097524,0.0004583593,0.00006275488],"category_scores_gemma":[0.00007253058,0.0001753158,0.0001417943,0.00005518429,0.0003107459,0.000004139844,0.00006814717,0.00008815446,3.737105e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002874286,"about_ca_system_score_gemma":0.000132143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002992679,"about_ca_topic_score_gemma":0.000008555047,"domain_scores_codex":[0.9988375,0.00009823796,0.0002772906,0.000397671,0.00007145626,0.0003178759],"domain_scores_gemma":[0.9992615,0.0001889887,0.0001526733,0.0001530968,0.0001505,0.00009324664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00134559,0.0001217528,0.001518051,0.00006731199,0.0001737812,7.611644e-7,0.0001076322,0.0002503502,0.9885413,0.002992458,0.0009067561,0.003974268],"study_design_scores_gemma":[0.001952222,0.00130097,0.001243837,0.000005664009,0.0001958422,0.00003951121,0.0001700647,0.001762899,0.9817963,0.001686239,0.009653356,0.0001930722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9717593,0.0007814824,0.02593013,0.0002379938,0.000414107,0.0007599164,0.00008001772,0.00001018593,0.00002688609],"genre_scores_gemma":[0.9908534,0.0001576552,0.007259972,0.0006668496,0.000506581,0.000360683,0.00007951785,0.00002254788,0.00009282974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01909408,"threshold_uncertainty_score":0.7149171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0565971139785305,"score_gpt":0.4013231025654033,"score_spread":0.3447259885868728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}