{"id":"W1974074916","doi":"10.1182/blood-2008-11-187757","title":"Expression of the leukemia oncogene Lmo2 is controlled by an array of tissue-specific elements dispersed over 100 kb and bound by Tal1/Lmo2, Ets, and Gata factors","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Christie (Canada)","funders":"Canadian Institutes of Health Research; Kay Kendall Leukaemia Fund; National Science Foundation; University of Cambridge; Cancer Research UK; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Biology; Haematopoiesis; Enhancer; GATA2; Ectopic expression; Chromatin immunoprecipitation; Cancer research; Transactivation; Transcription factor; Molecular biology; Stem cell; Cell biology; Promoter; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008275118,0.0004014041,0.0001931189,0.0003919379,0.0001919767,0.00027828,0.0001759047,0.0001414718,0.0009973082],"category_scores_gemma":[0.0001034544,0.0002077378,0.0001784133,0.0002566612,0.0002892756,0.0001230031,0.0003495682,0.0003102825,0.0003683583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004118498,"about_ca_system_score_gemma":0.0002219967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007785117,"about_ca_topic_score_gemma":0.001550791,"domain_scores_codex":[0.9998341,0.00001433335,0.000009651317,0.00005947243,0.00004692343,0.00003554449],"domain_scores_gemma":[0.999894,0.0000157096,0.0000438092,0.00001200396,0.000008242471,0.00002619587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003423908,0.000005802445,0.0004434327,0.000008654403,0.000002258392,0.00002195037,0.000006869323,0.00002318684,0.9989209,0.00003995997,0.0000114198,0.0004813678],"study_design_scores_gemma":[0.00002451109,0.000122259,0.04204816,0.000008741158,0.00002459185,0.0003884163,0.00004260098,0.001242002,0.9517572,0.0000786405,0.004255108,0.00000777431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938372,0.0007749099,0.003517722,0.00003509448,0.000007987513,0.00002038858,0.0006594304,0.0001261843,0.001021153],"genre_scores_gemma":[0.9916412,0.0004666599,0.002392353,0.00003692165,0.000007577286,0.00004061354,0.002218588,0.0000477684,0.003148396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009973082,"threshold_uncertainty_score":0.00333631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01163549402017508,"score_gpt":0.2793569684929445,"score_spread":0.2677214744727694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}