{"id":"W1974074916","doi":"10.1182/blood-2008-11-187757","title":"Expression of the leukemia oncogene Lmo2 is controlled by an array of tissue-specific elements dispersed over 100 kb and bound by Tal1/Lmo2, Ets, and Gata factors","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Christie (Canada)","funders":"Canadian Institutes of Health Research; Kay Kendall Leukaemia Fund; National Science Foundation; University of Cambridge; Cancer Research UK; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Biology; Haematopoiesis; Enhancer; GATA2; Ectopic expression; Chromatin immunoprecipitation; Cancer research; Transactivation; Transcription factor; Molecular biology; Stem cell; Cell biology; Promoter; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001825339,0.0001857925,0.0002797611,0.00002818946,0.00008679441,0.00002548226,0.0002359935,0.0001443388,0.00008194058],"category_scores_gemma":[0.00002101005,0.0001312821,0.00005565473,0.0000665943,0.0001576203,0.000008234246,0.0000628059,0.00008648389,3.859104e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001222236,"about_ca_system_score_gemma":0.00006184942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002761335,"about_ca_topic_score_gemma":0.00001882606,"domain_scores_codex":[0.9987327,0.0001248343,0.0002789472,0.0003589193,0.0002707616,0.0002338806],"domain_scores_gemma":[0.9991845,0.00001677952,0.0001545325,0.0004849253,0.00005155891,0.0001076267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009995537,0.0003413623,0.002835128,0.00001099284,0.00006971347,4.618472e-7,0.0001177248,7.469603e-7,0.9924174,9.370067e-7,0.002297135,0.0009088356],"study_design_scores_gemma":[0.00713542,0.002380947,0.001566043,0.00001754192,0.00003018938,0.000001547444,0.00007631571,0.000005355515,0.9840176,0.00001569192,0.004612606,0.0001407083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928755,0.006195879,0.00001796003,0.00004885493,0.00002234877,0.0004198957,0.0002813191,0.000003963813,0.0001343036],"genre_scores_gemma":[0.9982467,0.001055978,0.00004122998,0.00009753931,0.00003867981,0.000007949457,0.0001337428,0.00001926034,0.0003589557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008399775,"threshold_uncertainty_score":0.5353528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01163549402017508,"score_gpt":0.2793569684929445,"score_spread":0.2677214744727694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}