{"id":"W1974075750","doi":"10.1021/jm101642g","title":"Novel Interactions of Fluorinated Nucleotide Derivatives Targeting Orotidine 5′-Monophosphate Decarboxylase","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; University of New Brunswick; Ontario Institute for Cancer Research; Princess Margaret Cancer Centre; Canada Research Chairs","funders":"National Center for Research Resources; Canadian Institutes of Health Research","keywords":"Chemistry; Nucleotide; Biochemistry; Stereochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003383571,0.0001495866,0.0002496445,0.00003845265,0.00003464632,0.000005388852,0.0003106178,0.0001095571,0.0001399414],"category_scores_gemma":[0.0006002914,0.000122218,0.0001628845,0.0001257796,0.000162749,0.000008405386,0.00009116989,0.0003285682,0.000001015668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002003131,"about_ca_system_score_gemma":0.0001309199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001412789,"about_ca_topic_score_gemma":5.65308e-7,"domain_scores_codex":[0.9987966,0.00002408019,0.0005101135,0.0001680302,0.0002855034,0.0002156883],"domain_scores_gemma":[0.9987383,0.00001923464,0.0004003386,0.0001756828,0.0004585203,0.0002079415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004868572,0.0002527769,0.0004087166,0.00007144283,0.0001227561,0.00003448764,0.0000789079,0.000002680389,0.9966468,0.000006359634,0.0007528663,0.001135396],"study_design_scores_gemma":[0.0008677423,0.0003634437,0.000741882,0.0001317706,0.00004031825,0.0002096616,0.0002584226,0.00001618585,0.9950832,0.00004265352,0.002131122,0.0001135572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938889,0.001314692,0.002239764,0.0001423415,0.00009105198,0.00005322142,0.000005550571,0.000003862794,0.002260633],"genre_scores_gemma":[0.9945621,0.0002122726,0.004656184,0.0000693778,0.0002798846,0.000001731414,0.0000153349,0.00001592975,0.000187149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00241642,"threshold_uncertainty_score":0.4983907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0239860252053722,"score_gpt":0.2768598034174799,"score_spread":0.2528737782121077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}