{"id":"W1974075750","doi":"10.1021/jm101642g","title":"Novel Interactions of Fluorinated Nucleotide Derivatives Targeting Orotidine 5′-Monophosphate Decarboxylase","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; University of New Brunswick; Ontario Institute for Cancer Research; Princess Margaret Cancer Centre; Canada Research Chairs","funders":"National Center for Research Resources; Canadian Institutes of Health Research","keywords":"Chemistry; Nucleotide; Biochemistry; Stereochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001197041,0.000420996,0.0003636572,0.00009840597,0.00009463508,0.0002700154,0.0002544607,0.000416915,0.0006533316],"category_scores_gemma":[0.0001692186,0.0001092815,0.0001803092,0.0001040803,0.0001197184,0.0002461735,0.0001587813,0.0003633856,0.000180528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002798858,"about_ca_system_score_gemma":0.0001155558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004466214,"about_ca_topic_score_gemma":0.0006332135,"domain_scores_codex":[0.9998753,0.00003130993,0.000005183108,0.00002852499,0.00002935921,0.00003033893],"domain_scores_gemma":[0.9999371,0.00001484493,0.0000195206,0.000005038979,0.000007568906,0.00001600682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001017573,0.00003241854,0.0001012268,0.00006771526,0.000007754161,0.0001025982,0.00001300125,0.0003512902,0.9955493,0.0002089619,0.00003902145,0.003425093],"study_design_scores_gemma":[0.00001095655,0.0004046082,0.0006593176,0.00000465364,0.000009668902,0.0002247169,0.000005853456,0.001224736,0.9943691,0.00003269606,0.003046394,0.000007360821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977776,0.00879354,0.008694528,0.00009378709,0.00004914559,0.00005863754,0.0001779427,0.00008645348,0.004269938],"genre_scores_gemma":[0.9892146,0.002278518,0.005655168,0.00005596977,0.00001436856,0.00002378869,0.0001556624,0.00001116224,0.002590787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006533316,"threshold_uncertainty_score":0.002185583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0239860252053722,"score_gpt":0.2768598034174799,"score_spread":0.2528737782121077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}