{"id":"W1974127219","doi":"10.1038/ncomms5878","title":"A prominent and conserved role for YY1 in Xist transcriptional activation","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":150,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"XIST; X-inactivation; Biology; Repressor; YY1; Transcription factor; Genetics; X chromosome; Regulator; DNA methylation; Transcription (linguistics); Cell biology; Gene; Promoter; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003779606,0.0004354786,0.0003807287,0.0002769745,0.0005117462,0.0007899555,0.0004693728,0.0005820512,0.001789836],"category_scores_gemma":[0.0003717393,0.0001797709,0.0004397384,0.0002109657,0.0006573382,0.0004948088,0.0005681203,0.0009746733,0.0005552422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00051998,"about_ca_system_score_gemma":0.0005696504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008775301,"about_ca_topic_score_gemma":0.001094936,"domain_scores_codex":[0.9998093,0.00001759142,0.00001500587,0.00007957008,0.00004153698,0.00003689841],"domain_scores_gemma":[0.9998236,0.0000219385,0.00003147302,0.00003405906,0.00002711579,0.00006173241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002591998,0.00001522234,0.0009439579,0.0001587288,0.00002083326,0.0003679229,0.00003978951,0.0002413585,0.9862522,0.002915092,0.0004172684,0.008368385],"study_design_scores_gemma":[0.00006540663,0.0003219332,0.02647145,0.00003609701,0.00003698729,0.002887152,0.0001150871,0.001302273,0.9357105,0.001804402,0.03120951,0.00003925022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8489714,0.05783957,0.07260697,0.002639495,0.001375555,0.0001611081,0.002050001,0.001051754,0.01330408],"genre_scores_gemma":[0.9774311,0.005424313,0.009541767,0.0002397897,0.0001742482,0.00004221869,0.0008756468,0.0000641777,0.006206824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001789836,"threshold_uncertainty_score":0.005987585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01543646988628318,"score_gpt":0.2876265182834989,"score_spread":0.2721900483972157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}