{"id":"W1974127219","doi":"10.1038/ncomms5878","title":"A prominent and conserved role for YY1 in Xist transcriptional activation","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":150,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"XIST; X-inactivation; Biology; Repressor; YY1; Transcription factor; Genetics; X chromosome; Regulator; DNA methylation; Transcription (linguistics); Cell biology; Gene; Promoter; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001378625,0.00006413297,0.00007213681,0.00002367481,0.00008880543,0.00001654406,0.0001884804,0.0001540689,0.000005059848],"category_scores_gemma":[0.0001393196,0.00006147661,0.00003517893,0.00003503852,0.00008885523,0.000004129331,0.00005081456,0.000125547,7.826013e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005269127,"about_ca_system_score_gemma":0.00002141912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006432796,"about_ca_topic_score_gemma":0.0002640722,"domain_scores_codex":[0.9995496,0.00004945598,0.000145511,0.0001283472,0.00004749697,0.00007961493],"domain_scores_gemma":[0.9994906,0.0000678006,0.00003974387,0.0002940759,0.00007527487,0.00003254322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002809712,0.0005324541,0.02232076,0.00007980096,0.00006040346,1.101098e-7,0.0004186906,0.00001397208,0.8208548,0.130059,0.001975363,0.02340372],"study_design_scores_gemma":[0.002918972,0.0005481258,0.1941988,0.00005173168,0.00002648817,0.000008639013,0.0006895699,0.002761438,0.08166896,0.007156428,0.7095906,0.0003802369],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887088,0.001334261,0.0005943208,0.00614493,0.00004120071,0.000294972,0.00002317058,0.0000104166,0.002847907],"genre_scores_gemma":[0.9952902,0.0001856087,0.002955977,0.000788088,0.0000495769,0.0001001222,0.000258618,0.000006105769,0.0003657487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7391858,"threshold_uncertainty_score":0.2506943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01543646988628318,"score_gpt":0.2876265182834989,"score_spread":0.2721900483972157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}