{"id":"W1974172409","doi":"10.1038/nri2803","title":"Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules","year":2010,"lang":"en","type":"review","venue":"Nature reviews. Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":428,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Institut national de la recherche scientifique","keywords":"Cytotoxic T cell; Immunological synapse; Exocytosis; Cell biology; Secretion; Biology; Immune system; Effector; Granule (geology); Biogenesis; Chemistry; Immunology; T cell; Gene; T-cell receptor; In vitro; Genetics; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006787737,0.001862617,0.002303729,0.001646825,0.0003661669,0.001922077,0.002470834,0.002450612,0.002371687],"category_scores_gemma":[0.0004884229,0.0007476485,0.0005569511,0.001833796,0.001410369,0.002890194,0.001427027,0.002956098,0.003817219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001414759,"about_ca_system_score_gemma":0.001077464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006119387,"about_ca_topic_score_gemma":0.0006602146,"domain_scores_codex":[0.9997213,0.00002617282,0.0000430937,0.00006391287,0.0001048999,0.00004051151],"domain_scores_gemma":[0.9997302,0.00008012834,0.00005190093,0.00001457959,0.00007926939,0.00004405817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002883101,0.00008849073,0.0002417118,0.009212744,0.00007149637,0.0005669305,0.00007679451,0.001092792,0.02568174,0.01321016,0.04486442,0.9046044],"study_design_scores_gemma":[0.0000493298,0.00009693962,0.001636118,0.001629792,0.00009819191,0.002811211,0.0001018982,0.0004475455,0.006822467,0.01188328,0.9743699,0.00005336245],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002760945,0.9966142,0.0008577919,0.0004414709,0.0005755732,0.000009498712,0.00003995596,0.00002520719,0.001160245],"genre_scores_gemma":[0.001284252,0.9961511,0.0005249755,0.0002108719,0.0004173981,0.00001550887,0.00009424373,0.000004131376,0.001297328],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002470834,"threshold_uncertainty_score":0.01026487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01584316580042201,"score_gpt":0.2851280037190851,"score_spread":0.2692848379186631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}