{"id":"W1974203897","doi":"10.1074/jbc.m403954200","title":"A Conserved DpYR Motif in the Juxtamembrane Domain of the Met Receptor Family Forms an Atypical c-Cbl/Cbl-b Tyrosine Kinase Binding Domain Binding Site Required for Suppression of Oncogenic Activation","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Chemistry; Tyrosine kinase; Cancer research; Binding site; Tyrosine; Receptor tyrosine kinase; Cooperative binding; Molecular biology; Cell biology; Receptor; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001161998,0.0001885194,0.0004245662,0.00005601109,0.0001607207,0.00002484012,0.0006418054,0.0002267459,0.00002204877],"category_scores_gemma":[0.001298211,0.00009725076,0.0003001765,0.0004414933,0.0002866201,0.0002179498,0.00009011704,0.0004486462,8.733518e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001075444,"about_ca_system_score_gemma":0.0001069851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003510087,"about_ca_topic_score_gemma":5.272632e-7,"domain_scores_codex":[0.9978613,0.0002348309,0.0008945272,0.0002780459,0.000430272,0.0003010259],"domain_scores_gemma":[0.9978294,0.000742873,0.001023124,0.000233993,0.00008570463,0.00008492771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001721648,0.0002899981,0.0007129687,0.0000600482,0.000007221854,0.00001087653,0.0001790001,0.0001117342,0.9966173,0.0001068208,0.00001901184,0.0001634288],"study_design_scores_gemma":[0.001999844,0.0005763174,0.002109228,0.000376332,0.00001396365,0.00006076873,0.0004589003,0.00001711577,0.9923851,0.001734613,0.0001497237,0.0001180264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984875,0.00006102983,0.0004105259,0.0005718068,0.00008448931,0.0002835071,0.00006451114,0.000008129371,0.00002851484],"genre_scores_gemma":[0.9984882,0.00006144321,0.00102598,0.0002713615,0.0001139108,0.000009576588,0.00001055026,0.00001181288,0.000007131221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004232075,"threshold_uncertainty_score":0.3965771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06822893310537455,"score_gpt":0.2979665551036899,"score_spread":0.2297376219983154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}