{"id":"W1974203897","doi":"10.1074/jbc.m403954200","title":"A Conserved DpYR Motif in the Juxtamembrane Domain of the Met Receptor Family Forms an Atypical c-Cbl/Cbl-b Tyrosine Kinase Binding Domain Binding Site Required for Suppression of Oncogenic Activation","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Chemistry; Tyrosine kinase; Cancer research; Binding site; Tyrosine; Receptor tyrosine kinase; Cooperative binding; Molecular biology; Cell biology; Receptor; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001033793,0.0002821008,0.0002331405,0.000149509,0.0001436233,0.0001800685,0.0003014182,0.0002557705,0.001368528],"category_scores_gemma":[0.0001367803,0.0001292409,0.0002546927,0.0001482269,0.0002228352,0.0001524809,0.0002502101,0.0005292847,0.0007901385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003058069,"about_ca_system_score_gemma":0.000196039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005928786,"about_ca_topic_score_gemma":0.000665394,"domain_scores_codex":[0.9999052,0.00001757332,0.000007943459,0.00002006018,0.00003123499,0.0000179707],"domain_scores_gemma":[0.9999168,0.00001511688,0.00002833613,0.000007637417,0.000005087598,0.00002694208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009531085,0.0000151414,0.0003237185,0.00001946333,0.000004278691,0.0002221965,0.000007912485,0.00007514061,0.9978715,0.0001113363,0.00002580201,0.001228111],"study_design_scores_gemma":[0.00008597961,0.0003578358,0.02223118,0.00001244805,0.00003570367,0.005265594,0.00004557702,0.003319265,0.9620322,0.0001906457,0.006404632,0.00001898736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925573,0.0006953098,0.00558856,0.00007276996,0.00001760338,0.0000216662,0.0002350746,0.00005584023,0.00075583],"genre_scores_gemma":[0.9951202,0.0002168887,0.003216766,0.00005365792,0.000006395423,0.00001937321,0.0004561259,0.00001235987,0.0008981766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001368528,"threshold_uncertainty_score":0.004578173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06822893310537455,"score_gpt":0.2979665551036899,"score_spread":0.2297376219983154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}