{"id":"W1974218564","doi":"10.1016/j.bmcl.2009.10.040","title":"N-(4-(6,7-Disubstituted-quinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: A novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Liver physiology and pathology","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Chemistry; In vitro; Receptor tyrosine kinase; Tyrosine kinase; In vivo; Stereochemistry; IC50; Kinase; Enzyme; Carboxamide; Pharmacokinetics; Molecular model; Pharmacology; Receptor; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002891526,0.0006121382,0.0004436877,0.0003413369,0.0002052449,0.0002351109,0.0008463758,0.0003226604,0.001998963],"category_scores_gemma":[0.000137664,0.0001685407,0.0001893901,0.0002176366,0.0002260612,0.0003042598,0.0002969534,0.0005807221,0.0006478748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005111921,"about_ca_system_score_gemma":0.0002937073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000726696,"about_ca_topic_score_gemma":0.002152253,"domain_scores_codex":[0.9998893,0.00001976932,0.000005801809,0.00002071511,0.00002052507,0.00004392634],"domain_scores_gemma":[0.9999528,0.000005673892,0.00001409178,0.000002934786,0.000007110597,0.00001740091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001540358,0.0005113783,0.000471074,0.0007501959,0.00005481636,0.0008913022,0.0002576853,0.002423859,0.9047522,0.004791285,0.005140517,0.07841539],"study_design_scores_gemma":[0.002940355,0.01201761,0.01016341,0.0001498488,0.0002557746,0.005137305,0.0001727762,0.01107833,0.8279544,0.0008942913,0.1290659,0.0001699981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8889757,0.04653334,0.02801979,0.001204265,0.0007231912,0.000449786,0.001483041,0.001481173,0.03112974],"genre_scores_gemma":[0.9720405,0.01143494,0.006654433,0.0003388282,0.0001057711,0.0002304002,0.000565352,0.00003693754,0.008592817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001998963,"threshold_uncertainty_score":0.006687164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0150330681294251,"score_gpt":0.2348204066449049,"score_spread":0.2197873385154798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}