{"id":"W1974220691","doi":"10.1016/j.cell.2004.06.013","title":"Exploration of Essential Gene Functions via Titratable Promoter Alleles","year":2004,"lang":"en","type":"article","venue":"Cell","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":617,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"","keywords":"Biology; Ribosome biogenesis; Genetics; Gene; Gene knockout; Phenotype; Gene expression profiling; Mutant; Computational biology; Gene expression; Ribosome; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005769234,0.0007722191,0.0003431026,0.0005031524,0.0002383309,0.0006801459,0.0009695348,0.0005375048,0.002365174],"category_scores_gemma":[0.0006476732,0.0003992036,0.0004669645,0.0003439195,0.0008840523,0.0006355219,0.0008036164,0.001951567,0.0005758604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005572206,"about_ca_system_score_gemma":0.0002683245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003129295,"about_ca_topic_score_gemma":0.0004414208,"domain_scores_codex":[0.9997154,0.00005249633,0.00003341481,0.00006230752,0.00009439404,0.00004203228],"domain_scores_gemma":[0.9991704,0.0004502861,0.0001168816,0.0001095111,0.00004303226,0.0001099635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008344815,0.00001978307,0.00007443311,0.00002024159,0.000002426624,0.00003569099,0.00001048943,0.0001166228,0.997766,0.00086963,0.00001008926,0.0009910978],"study_design_scores_gemma":[0.00002375745,0.0000813247,0.0002841856,0.000005020613,0.00001217585,0.0001637847,0.00001799218,0.001249645,0.9970747,0.0002851325,0.0007961032,0.000006238904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9383469,0.001215857,0.05602799,0.0002509602,0.00004953915,0.00008764765,0.0005151026,0.0003919649,0.003114066],"genre_scores_gemma":[0.9772778,0.0009968829,0.01774696,0.0000821014,0.00001924021,0.00005599235,0.0005927079,0.0003330139,0.002895278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002365174,"threshold_uncertainty_score":0.007912278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01518307996115763,"score_gpt":0.2483703765963833,"score_spread":0.2331872966352257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}