{"id":"W1974220691","doi":"10.1016/j.cell.2004.06.013","title":"Exploration of Essential Gene Functions via Titratable Promoter Alleles","year":2004,"lang":"en","type":"article","venue":"Cell","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":617,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"","keywords":"Biology; Ribosome biogenesis; Genetics; Gene; Gene knockout; Phenotype; Gene expression profiling; Mutant; Computational biology; Gene expression; Ribosome; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004733404,0.00005884138,0.00005283567,0.00002236662,0.0000382572,0.000009073942,0.00007780855,0.00006216472,0.00005085022],"category_scores_gemma":[0.000005040406,0.00005450703,0.00003954411,0.00005251818,0.00003827077,0.000004136623,0.00004900105,0.00003961956,0.00005679308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000494288,"about_ca_system_score_gemma":0.00006141813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000185084,"about_ca_topic_score_gemma":0.00001832893,"domain_scores_codex":[0.9995306,0.0000133677,0.00009405522,0.0001477603,0.00009338223,0.0001208762],"domain_scores_gemma":[0.9996879,0.000001281326,0.00002486281,0.0001686367,0.0000760515,0.00004124959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002654438,0.0001023291,0.00002889818,0.00001858055,0.000009486641,8.554981e-7,0.00002624586,0.001088839,0.9981552,0.00001221856,0.000315245,0.0002155516],"study_design_scores_gemma":[0.0003172009,0.0001883313,0.0000716509,0.000002590999,0.000005653023,0.00000210137,0.00002256897,0.00002950185,0.994417,0.0002542863,0.004627746,0.00006138247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9474674,0.0004531591,0.04770574,0.00008036033,0.0001029169,0.000129582,0.00001652512,0.0000055001,0.004038841],"genre_scores_gemma":[0.99553,0.0001032733,0.001221908,0.00001810956,0.0001595803,0.00001261925,0.0001857357,0.000009900722,0.002758851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04806265,"threshold_uncertainty_score":0.2222732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01518307996115763,"score_gpt":0.2483703765963833,"score_spread":0.2331872966352257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}