{"id":"W1974229450","doi":"10.1038/nature04662","title":"Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes","year":2006,"lang":"en","type":"article","venue":"Nature","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":480,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; Western University; McGill University; Canada Research Chairs; University of Toronto; McGill University Health Centre; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"Nephrin; Podocyte; Slit diaphragm; Cell biology; Signal transducing adaptor protein; Proto-oncogene tyrosine-protein kinase Src; Actin cytoskeleton; SH3 domain; Cytoskeleton; Actin; Phosphotyrosine-binding domain; Biology; Chemistry; Phosphorylation; SH2 domain; Kidney; Biochemistry; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009103357,0.0001267726,0.0002020868,0.00006649407,0.00005332406,0.0000141139,0.0001203176,0.0003771051,0.00007893724],"category_scores_gemma":[0.0005151772,0.00007331171,0.0001325852,0.00028118,0.00003392746,0.00003726649,0.0000418776,0.0008443999,0.00003349971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002579552,"about_ca_system_score_gemma":0.000163837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001665753,"about_ca_topic_score_gemma":0.00002770952,"domain_scores_codex":[0.9991029,0.00002751071,0.0001703845,0.0001746814,0.0003363127,0.0001882165],"domain_scores_gemma":[0.9992583,0.00003573288,0.00006679344,0.0003210795,0.0001217058,0.0001964143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001615762,0.0004297097,0.009826764,0.0008927513,0.0001268623,0.00009780227,0.0003039448,0.00004523703,0.1944374,0.005305576,0.7603812,0.02653704],"study_design_scores_gemma":[0.000771115,0.0003521724,0.1337461,0.0003922795,0.0000945461,0.00001943924,0.00008248927,0.00002807966,0.07623151,0.0002713536,0.7878644,0.0001464648],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8646133,0.007516182,0.00005263131,0.1146423,0.0003449823,0.001581522,0.0002484985,0.0001090883,0.0108915],"genre_scores_gemma":[0.9883175,0.00004890476,0.0008258531,0.006074036,0.001097338,0.00003034931,0.00005039718,0.00001952993,0.003536062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1239193,"threshold_uncertainty_score":0.3668544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005683743585274783,"score_gpt":0.2541535871263619,"score_spread":0.2484698435410871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}