{"id":"W1974238889","doi":"10.1002/anie.200805966","title":"Colorimetric Sensing by Using Allosteric‐DNAzyme‐Coupled Rolling Circle Amplification and a Peptide Nucleic Acid–Organic Dye Probe","year":2009,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Deoxyribozyme; Peptide nucleic acid; Allosteric regulation; Naked eye; Nucleic acid; Rolling circle replication; Chemistry; DNA; Duplex (building); Molecule; Combinatorial chemistry; RNA; Biophysics; Nanotechnology; Biochemistry; Polymerase; Detection limit; Biology; Receptor; Materials science; Organic chemistry; Chromatography; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001579119,0.0001670803,0.0001466103,0.0001102778,0.000123621,0.00008046611,0.0001060573,0.000156813,0.000005920758],"category_scores_gemma":[0.0001222713,0.0001816687,0.0000716531,0.0001925096,0.0000564412,0.00002944309,0.00004457339,0.00009735444,0.000001790428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008829233,"about_ca_system_score_gemma":0.0000253768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001555229,"about_ca_topic_score_gemma":0.000005389783,"domain_scores_codex":[0.9989124,0.00001977747,0.0002571796,0.0004144469,0.0002142294,0.0001819643],"domain_scores_gemma":[0.9993241,0.00001221667,0.0001987376,0.000168513,0.0002314604,0.00006501102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005127175,0.00004875783,0.00009594846,0.000005013444,0.00004406706,0.000001921713,0.00001674907,0.000003107035,0.9952895,0.000004493387,0.0007190573,0.003720106],"study_design_scores_gemma":[0.0003166363,0.0001104914,0.0005233869,0.00003652943,0.00004630085,0.00003786467,0.00004245368,0.001086313,0.9957054,0.0002370976,0.001641822,0.0002157007],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8929559,0.0003758085,0.1053303,0.0005794644,0.0001792782,0.0001721419,0.00004054089,0.00007853007,0.0002880218],"genre_scores_gemma":[0.9909561,0.0002867528,0.006526717,0.000478471,0.0006626456,0.000002475962,0.0009498517,0.00001868824,0.0001183265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09880359,"threshold_uncertainty_score":0.7408236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0114789569246863,"score_gpt":0.2643711811240023,"score_spread":0.252892224199316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}