{"id":"W1974314535","doi":"10.1016/j.febslet.2005.03.077","title":"Induction of IGFBP‐1 expression by amino acid deprivation of HepG2 human hepatoma cells involves both a transcriptional activation and an mRNA stabilization due to its 3′UTR","year":2005,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"York University","keywords":"Messenger RNA; Amino acid; Untranslated region; Three prime untranslated region; Downregulation and upregulation; Chemistry; Gene expression; Cell biology; Biology; Molecular biology; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000165222,0.0001866344,0.0002937305,0.0003048849,0.0000952342,0.00001501689,0.0000748008,0.0001423323,0.00003837623],"category_scores_gemma":[0.0000370455,0.0001815922,0.00005599209,0.000283667,0.0000586336,0.0007783178,0.00001501076,0.0001450109,0.000002379546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009431501,"about_ca_system_score_gemma":0.00002454571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006035826,"about_ca_topic_score_gemma":0.00001133132,"domain_scores_codex":[0.9985035,0.00007663789,0.0004990773,0.0003246253,0.0004123768,0.0001837711],"domain_scores_gemma":[0.9992636,0.00002277747,0.0002308149,0.0002121834,0.0001339054,0.0001367313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002108653,0.0002391402,0.01159035,0.0001250923,0.00002005888,6.337085e-7,0.002308801,0.00003590748,0.9826966,0.00005484759,0.001172286,0.00154542],"study_design_scores_gemma":[0.0009387227,0.0003820937,0.1659463,0.0001225589,0.00003355852,0.000003244525,0.0001859954,0.0001608069,0.8316636,0.00001449927,0.0004153543,0.0001332715],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938049,0.00006578044,0.003964812,0.001452996,0.00007716211,0.0005264818,0.00002905484,0.00004494987,0.00003384314],"genre_scores_gemma":[0.9971151,0.00002254829,0.001297039,0.001007136,0.000178839,0.00002371469,0.0003148531,0.0000281824,0.00001254266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1543559,"threshold_uncertainty_score":0.7405113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02150512984686087,"score_gpt":0.2555268044625145,"score_spread":0.2340216746156536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}