{"id":"W1974318341","doi":"10.1371/journal.pgen.1004750","title":"TIF-IA-Dependent Regulation of Ribosome Synthesis in Drosophila Muscle Is Required to Maintain Systemic Insulin Signaling and Larval Growth","year":2014,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Institute of Genetics; Canadian Institutes of Health Research; Alberta Innovates - Health Solutions","keywords":"Biology; Cell biology; Insulin; Drosophila melanogaster; Larva; Drosophila (subgenus); Ribosome; Protein biosynthesis; Translation (biology); Genetics; Endocrinology; RNA; Ecology; Gene; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000728683,0.000446473,0.0002159029,0.0002701294,0.0001970927,0.0003099429,0.0003161254,0.0003593349,0.00128841],"category_scores_gemma":[0.0001135329,0.0001945345,0.0002822573,0.0001189869,0.0002272695,0.0002240038,0.0003333163,0.000689882,0.000614771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007293678,"about_ca_system_score_gemma":0.0002889239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001795154,"about_ca_topic_score_gemma":0.00372313,"domain_scores_codex":[0.9998864,0.000009072566,0.00001446946,0.00004310484,0.00002547569,0.00002143594],"domain_scores_gemma":[0.9998424,0.00001457979,0.0000615579,0.00001607187,0.0000153169,0.00005005286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002985995,0.000005036055,0.0001655819,0.00001767369,0.000002253183,0.00002038679,0.00000425566,0.00002595853,0.9992006,0.0000393619,0.0000226883,0.0004662559],"study_design_scores_gemma":[0.00001743369,0.00007349483,0.02006004,0.0000113798,0.00001347228,0.0001434038,0.00002193743,0.001360195,0.9757938,0.00004459506,0.002453657,0.000006530032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879638,0.002870803,0.004170451,0.0001866142,0.0000557778,0.00003077621,0.001278989,0.0002104506,0.003232278],"genre_scores_gemma":[0.9896408,0.0006970157,0.003316928,0.000147192,0.00001206768,0.00006912152,0.001210364,0.00009251546,0.004814061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001795154,"threshold_uncertainty_score":0.005291939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01390396682770821,"score_gpt":0.2461100589135696,"score_spread":0.2322060920858614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}