{"id":"W1974389826","doi":"10.1126/science.1230161","title":"A Strategy for Modulation of Enzymes in the Ubiquitin System","year":2013,"lang":"en","type":"article","venue":"Science","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":297,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Institute for Research in Immunology and Cancer; Hospital for Sick Children; Structural Genomics Consortium; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; Wellcome Trust","keywords":"Ubiquitin; Ubiquitin ligase; Deubiquitinating enzyme; Ubiquitin-conjugating enzyme; Ubiquitin-Protein Ligases; Enzyme; Function (biology); Ubiquitins; Biology; Cell biology; Biochemistry; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000322446,0.0006293173,0.0004056426,0.0003474866,0.0002866673,0.0005712114,0.000474374,0.0004032351,0.0009488012],"category_scores_gemma":[0.0001873728,0.0002411859,0.0003313074,0.0002937795,0.0003504289,0.0004035708,0.0004954309,0.001031182,0.000530485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003859561,"about_ca_system_score_gemma":0.0002692516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002528939,"about_ca_topic_score_gemma":0.0004535256,"domain_scores_codex":[0.9996951,0.00004931633,0.00002809167,0.00008360079,0.00009545161,0.00004843965],"domain_scores_gemma":[0.9998828,0.00002065087,0.00002522343,0.00003209435,0.00001638861,0.00002288251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005450297,0.00005722237,0.0000833023,0.00003597853,0.00001172445,0.00005789767,0.00001280714,0.000235817,0.9919045,0.001670914,0.0001607179,0.005714586],"study_design_scores_gemma":[0.00001956317,0.0002887405,0.0002365403,0.000002838971,0.00001484642,0.000209238,0.00000494862,0.0006871052,0.9895533,0.0002796533,0.008695189,0.000007869743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7086579,0.007445676,0.2652166,0.001234671,0.000492112,0.0006521825,0.0011381,0.001253815,0.01390882],"genre_scores_gemma":[0.8945697,0.004406809,0.09075671,0.0006897864,0.00007148248,0.0003518763,0.000735576,0.0001524657,0.008265711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009488012,"threshold_uncertainty_score":0.003174007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02437936901806519,"score_gpt":0.2738553245266764,"score_spread":0.2494759555086112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}