{"id":"W1974389826","doi":"10.1126/science.1230161","title":"A Strategy for Modulation of Enzymes in the Ubiquitin System","year":2013,"lang":"en","type":"article","venue":"Science","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":297,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Institute for Research in Immunology and Cancer; Hospital for Sick Children; Structural Genomics Consortium; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; Wellcome Trust","keywords":"Ubiquitin; Ubiquitin ligase; Deubiquitinating enzyme; Ubiquitin-conjugating enzyme; Ubiquitin-Protein Ligases; Enzyme; Function (biology); Ubiquitins; Biology; Cell biology; Biochemistry; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004654548,0.00003615889,0.00003940708,0.0000204178,0.00004329238,0.00001999692,0.0002141692,0.00002529324,0.00000555286],"category_scores_gemma":[0.00005093087,0.00002459577,0.00001798526,0.0001227321,0.0001098918,0.000005532338,0.00002791551,0.00001738958,0.00000304934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005608293,"about_ca_system_score_gemma":0.00005100156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002853203,"about_ca_topic_score_gemma":0.00001175814,"domain_scores_codex":[0.9995558,0.00002146517,0.00008835891,0.0001259944,0.00009358209,0.0001147903],"domain_scores_gemma":[0.999737,0.000009244394,0.00003783729,0.000145699,0.00005472699,0.00001549666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000004543045,0.00001126367,0.0007104987,0.00002448966,7.132966e-7,7.168179e-8,0.000117309,0.000157913,0.9918515,0.004121896,0.00009729147,0.002902487],"study_design_scores_gemma":[0.0001467411,0.0001687432,0.01340529,0.00001323304,0.000001152876,0.000003770935,0.0004647825,0.003501506,0.9810441,0.0005321552,0.000662423,0.00005610109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949903,0.0001019038,0.001198336,0.00007317014,0.00003025827,0.0003643127,0.000003613865,0.00000263365,0.003235456],"genre_scores_gemma":[0.9993253,0.000001650162,0.0004373683,0.00005434308,0.00003168235,0.00008505116,0.000004074761,0.000002052717,0.00005852771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01269479,"threshold_uncertainty_score":0.1002986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02437936901806519,"score_gpt":0.2738553245266764,"score_spread":0.2494759555086112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}