{"id":"W1974393958","doi":"10.1007/s13402-014-0189-1","title":"Validation of DNA promoter hypermethylation biomarkers in breast cancer — a short report","year":2014,"lang":"en","type":"article","venue":"Cellular Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Genome British Columbia","keywords":"Breast cancer; DNA methylation; GSTP1; Methylation; Carcinogenesis; Cancer; Oncology; Biomarker; Cancer research; Promoter; Biology; Medicine; Gene; Internal medicine; Genotype; Genetics; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007106352,0.0001067188,0.0001818982,0.00009037003,0.00002379794,0.00000531531,0.00008868604,0.0002471037,0.00003275753],"category_scores_gemma":[0.00006382234,0.0001072932,0.00006004585,0.0001205502,0.00006517629,0.000004248117,0.00004591181,0.00005967441,0.000002265816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004342616,"about_ca_system_score_gemma":0.0001040926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006947944,"about_ca_topic_score_gemma":0.00004279952,"domain_scores_codex":[0.9988753,0.0001843605,0.0003702819,0.0003032218,0.0001059876,0.0001608484],"domain_scores_gemma":[0.9994003,0.00001837786,0.0001485538,0.0002697567,0.0001177248,0.00004535153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000561944,0.00007677916,0.05660613,0.00001709328,0.00002998165,0.000007009455,0.00003705923,0.0001815647,0.9276842,0.00001640426,0.00003010341,0.01525747],"study_design_scores_gemma":[0.0003687778,0.0001832547,0.03299714,0.00001052019,0.00002293729,0.00001788944,0.00001393434,0.0004989706,0.9574354,0.000180688,0.00814592,0.0001245702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922344,0.0003330772,0.004945653,0.0002589528,0.0002274397,0.0002043455,0.000007290249,0.000005620487,0.001783211],"genre_scores_gemma":[0.9986066,0.00009404199,0.0007113009,0.00002470318,0.0001632567,0.00003292427,0.0002620907,0.00001692545,0.00008817022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02975119,"threshold_uncertainty_score":0.4375288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01350470027354454,"score_gpt":0.2846310234316597,"score_spread":0.2711263231581152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}