{"id":"W1974408803","doi":"10.1371/journal.pone.0004136","title":"Strong Eukaryotic IRESs Have Weak Secondary Structure","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; Ontario Genomics; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Internal ribosome entry site; Eukaryotic translation; Biology; Protein secondary structure; Nucleic acid secondary structure; Start codon; Five prime untranslated region; Ribosome; Untranslated region; Eukaryotic initiation factor; Translation (biology); Genetics; Nucleic acid structure; RNA; Cell biology; Messenger RNA; Computational biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005166343,0.0003469483,0.0004374797,0.0003566094,0.0002139228,0.0005150309,0.0001861487,0.0003834341,0.001181429],"category_scores_gemma":[0.0008645654,0.000161911,0.0003196077,0.0002093243,0.0004195437,0.0003170702,0.0002552572,0.0003165851,0.0007413116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002238618,"about_ca_system_score_gemma":0.0001644546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001257481,"about_ca_topic_score_gemma":0.0001849555,"domain_scores_codex":[0.9997739,0.00002832452,0.00003103849,0.00007850083,0.00005982266,0.00002839952],"domain_scores_gemma":[0.9982429,0.0005082412,0.0006578576,0.0001570387,0.0003026426,0.0001313782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002188638,0.00003147675,0.02190891,0.0002145009,0.00004472946,0.0001353152,0.00003384536,0.0007550135,0.9717713,0.000637088,0.00006721081,0.004181752],"study_design_scores_gemma":[0.00004207274,0.001187769,0.1371799,0.00005708708,0.0001759164,0.002586513,0.00009986194,0.006134341,0.8452517,0.002417754,0.004838705,0.00002827129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985122,0.001883139,0.01118256,0.00006837001,0.00001266415,0.00002169685,0.0003397887,0.0001416568,0.001228094],"genre_scores_gemma":[0.993637,0.0003025738,0.005002826,0.00005296516,0.00001472138,0.00001493702,0.0005985811,0.00001554933,0.0003609532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001181429,"threshold_uncertainty_score":0.003952265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01827643132349668,"score_gpt":0.2177932663685375,"score_spread":0.1995168350450408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}