{"id":"W1974414813","doi":"10.1016/j.clml.2011.05.021","title":"509 The OPAL Study: A Phase II Study to Evaluate the Efficacy, Safety and Tolerability of Tosedostat (CHR-2797) in Elderly Subjects with Treatment Refractory or Relapsed Acute Myeloid Leukemia","year":2011,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Tolerability; Refractory (planetary science); Myeloid leukemia; Internal medicine; Safety profile; Oncology; Phases of clinical research; Adverse effect; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008428741,0.001222648,0.001689649,0.0004616769,0.0002792527,0.0006598234,0.0006933169,0.0007962859,0.003914255],"category_scores_gemma":[0.0005929891,0.0004129004,0.0009797586,0.0004089503,0.001013,0.0006001262,0.0003557602,0.002493426,0.0007927959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005812229,"about_ca_system_score_gemma":0.001213752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001167229,"about_ca_topic_score_gemma":0.003221146,"domain_scores_codex":[0.9997254,0.0001295334,0.0000116044,0.00003514262,0.00002916378,0.00006917601],"domain_scores_gemma":[0.9995116,0.0000816939,0.00008255699,0.00004182492,0.00002408009,0.0002582497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8103725,0.03979305,0.01356274,0.0007820621,0.001994266,0.0004221309,0.0002208032,0.001726154,0.04418438,0.0005623886,0.005242391,0.08113707],"study_design_scores_gemma":[0.7127869,0.251179,0.02520633,0.00003229834,0.001015917,0.0003689215,0.00009293991,0.0008515906,0.003717941,0.0002716257,0.004433036,0.00004357826],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941299,0.001111888,0.0003188349,0.0002607181,0.00006522311,0.0008220662,0.00142641,0.00007378295,0.001791143],"genre_scores_gemma":[0.9881295,0.001896445,0.001111305,0.001017666,0.0001716136,0.001130492,0.003787195,0.00003977999,0.002716033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003914255,"threshold_uncertainty_score":0.01309454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04674116976032461,"score_gpt":0.3648335013747979,"score_spread":0.3180923316144733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}