{"id":"W1974423751","doi":"10.1371/journal.ppat.1003466","title":"Critical Significance of the Region between Helix 1 and 2 for Efficient Dominant-Negative Inhibition by Conversion-Incompetent Prion Protein","year":2013,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of General Medical Sciences; National Institute of Neurological Disorders and Stroke; Alberta Prion Research Institute; National Institutes of Health","keywords":"Intracellular; Gene isoform; Prion protein; Scrapie; Biology; Cell biology; Helix (gastropod); Proteinase K; Protease; Chemistry; Biophysics; Biochemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001333456,0.000294099,0.0001616262,0.0001071644,0.00009322583,0.0002731531,0.0001597975,0.0002081447,0.0007340487],"category_scores_gemma":[0.0001653104,0.0001205772,0.0001460244,0.00006794911,0.0001858444,0.0001567835,0.0001543603,0.0004314145,0.0003067132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001761853,"about_ca_system_score_gemma":0.0001698047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002758371,"about_ca_topic_score_gemma":0.0003156138,"domain_scores_codex":[0.999902,0.00002278924,0.00001128251,0.00002439741,0.00002259219,0.00001683412],"domain_scores_gemma":[0.9998253,0.00006858204,0.00004582818,0.00001568834,0.000009093025,0.00003554069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006929629,0.00001505398,0.0001033315,0.00001180767,0.000001517585,0.00004383586,0.000005550228,0.00005387385,0.999158,0.00004966866,0.000007526558,0.0004805373],"study_design_scores_gemma":[0.00002027864,0.0003472198,0.00644542,0.000009728079,0.00001506288,0.0007794329,0.00001907961,0.001059253,0.989504,0.00007521096,0.001719663,0.000005619382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964054,0.001055054,0.001512558,0.00004774972,0.00001266553,0.00001602407,0.0001170333,0.0000323786,0.0008012222],"genre_scores_gemma":[0.9978791,0.0002846496,0.001229137,0.00003812505,0.000007831504,0.00001544759,0.0002004709,0.00001235437,0.0003328202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007340487,"threshold_uncertainty_score":0.002455652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01308944878182356,"score_gpt":0.237763709199792,"score_spread":0.2246742604179685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}