{"id":"W1974442869","doi":"10.1021/ol0609863","title":"From Macrocycle Dipeptide Lactams To Azabicyclo[X.Y.0]alkanone Amino Acids:  A Transannular Cyclization Route for Peptide Mimic Synthesis","year":2006,"lang":"en","type":"article","venue":"Organic Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Dipeptide; Chemistry; Bicyclic molecule; Stereochemistry; Ring (chemistry); Peptide; Beta-lactam; Amino acid; Electrophile; Combinatorial chemistry; Catalysis; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001009856,0.0002746028,0.0003092827,0.00005481286,0.0001124262,0.00006490906,0.0003020116,0.000159317,0.0001630022],"category_scores_gemma":[0.0001161456,0.0002698761,0.0002886543,0.0001760204,0.00003978177,0.00000951931,0.00005342486,0.00006464577,0.00004883457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006912924,"about_ca_system_score_gemma":0.00002085967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003677742,"about_ca_topic_score_gemma":0.0002796559,"domain_scores_codex":[0.9983847,0.00004318287,0.0003483571,0.0006389427,0.0001780998,0.0004067609],"domain_scores_gemma":[0.999234,0.00006654301,0.00009803227,0.000438204,0.00004137447,0.000121854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006529618,0.0000730368,0.001295629,0.00001410791,0.0001149134,0.000002988267,0.00003763015,0.00008178342,0.9906189,0.000003909136,0.006679749,0.001012089],"study_design_scores_gemma":[0.0003943625,0.00002734152,0.001674044,0.00002941686,0.0001933357,0.000002295204,0.00003830064,0.0000806547,0.9827746,0.00007028632,0.01433895,0.0003764203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.957639,0.0001076031,0.03761942,0.004017559,0.00005603814,0.0002381874,0.0001973657,0.00003771904,0.00008704072],"genre_scores_gemma":[0.9929969,0.00002498873,0.003221275,0.002064848,0.0008058208,0.00008610753,0.0005195243,0.00007328004,0.000207307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03535778,"threshold_uncertainty_score":0.9999753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003915116014631232,"score_gpt":0.1991515187549497,"score_spread":0.1952364027403185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}