{"id":"W1974452780","doi":"10.1039/c4tx00116h","title":"The Hepatic Reductase Null (HRN<sup>™</sup>) and Reductase Conditional Null (RCN) mouse models as suitable tools to study metabolism, toxicity and carcinogenicity of environmental pollutants","year":2014,"lang":"en","type":"article","venue":"Toxicology Research","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Cancer Research UK; King's College London; University of Dundee; Grantová Agentura České Republiky; Univerzita Karlova v Praze","keywords":"Reductase; Null (SQL); Carcinogen; Metabolism; Chemistry; Biochemistry; Enzyme; Toxicology; Biology; Computer science; Data mining","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.007993001,0.0004274994,0.0007075724,0.0003886715,0.00204143,0.0001062088,0.000609069,0.0006476284,0.0007685329],"category_scores_gemma":[0.001197764,0.0003746263,0.0001039726,0.0004716959,0.001623778,0.000409905,0.0007475179,0.002181075,0.0001163515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002122727,"about_ca_system_score_gemma":0.0002248258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002855163,"about_ca_topic_score_gemma":0.0001310302,"domain_scores_codex":[0.9903892,0.005868054,0.0007766354,0.0009433987,0.0007417137,0.00128095],"domain_scores_gemma":[0.9959216,0.002350255,0.0001884969,0.0006138035,0.00017605,0.0007497554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004315504,0.006212771,0.009572104,0.0001291466,0.0009766527,0.00009575674,0.01146454,0.002446064,0.9155557,0.01037568,0.001303175,0.03755293],"study_design_scores_gemma":[0.01055001,0.006189978,0.02735628,0.00002885943,0.0005333452,0.0004995477,0.01047878,0.03486792,0.8687521,0.03151518,0.007939981,0.001288028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925255,0.0006088801,0.00004478474,0.001535888,0.0002124686,0.003122922,0.00114192,0.00005681679,0.0007508686],"genre_scores_gemma":[0.9971182,0.0004096033,0.0001347615,0.0006911863,0.0002463877,0.0004832222,0.0000311619,0.00004974493,0.0008357346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04680359,"threshold_uncertainty_score":0.9998705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1765781729303148,"score_gpt":0.4379840723037953,"score_spread":0.2614058993734806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}