{"id":"W1974452780","doi":"10.1039/c4tx00116h","title":"The Hepatic Reductase Null (HRN<sup>™</sup>) and Reductase Conditional Null (RCN) mouse models as suitable tools to study metabolism, toxicity and carcinogenicity of environmental pollutants","year":2014,"lang":"en","type":"article","venue":"Toxicology Research","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Cancer Research UK; King's College London; University of Dundee; Grantová Agentura České Republiky; Univerzita Karlova v Praze","keywords":"Reductase; Null (SQL); Carcinogen; Metabolism; Chemistry; Biochemistry; Enzyme; Toxicology; Biology; Computer science; Data mining","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008859083,0.0009805762,0.0007998964,0.001340922,0.0002437924,0.0006666013,0.0006914437,0.0007119563,0.00303412],"category_scores_gemma":[0.0003089548,0.0003553393,0.000862072,0.0005655327,0.0005600002,0.0005616216,0.0004204928,0.001369224,0.001079547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003089595,"about_ca_system_score_gemma":0.0003602591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005722555,"about_ca_topic_score_gemma":0.001350116,"domain_scores_codex":[0.9995813,0.00007984737,0.0000538661,0.00008924352,0.0001570492,0.00003874069],"domain_scores_gemma":[0.9996209,0.00008947375,0.0001279292,0.00005003461,0.00006179735,0.00004973519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002965622,0.00006012634,0.0007203593,0.0005105514,0.00004492214,0.0004578,0.00003345498,0.0001422819,0.9794379,0.002366213,0.0007729709,0.01515683],"study_design_scores_gemma":[0.00008179231,0.001436554,0.007727227,0.0002179284,0.0005201232,0.007242411,0.000145165,0.001051946,0.8858944,0.001950778,0.09365376,0.00007797327],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5439398,0.1739084,0.2305096,0.002965538,0.001404159,0.0006936865,0.01242419,0.003009116,0.03114545],"genre_scores_gemma":[0.623023,0.1948725,0.1078719,0.001573573,0.0003811985,0.0009469234,0.01635534,0.0007120171,0.05426349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00303412,"threshold_uncertainty_score":0.01015013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1765781729303148,"score_gpt":0.4379840723037953,"score_spread":0.2614058993734806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}