{"id":"W1974478001","doi":"10.1016/j.jaci.2009.06.048","title":"Reduced central tolerance in Omenn syndrome leads to immature self-reactive oligoclonal T cells","year":2009,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":57,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Biology; Peripheral tolerance; Immunology; Autoimmune regulator; T cell; Central tolerance; Immune system; Population; Gene expression; Immune tolerance; Negative selection; Gene; Molecular biology; Autoimmunity; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007041901,0.0003015158,0.0009436001,0.0002704349,0.0001482535,0.00002112042,0.000521825,0.0007214191,0.0001794309],"category_scores_gemma":[0.0001544788,0.0002582079,0.000305002,0.000289223,0.0002939273,0.0002274588,0.00008472093,0.001692143,0.00009969679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007030811,"about_ca_system_score_gemma":0.0001872649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002157718,"about_ca_topic_score_gemma":0.000008787117,"domain_scores_codex":[0.9969132,0.0004652884,0.001454098,0.0003609603,0.00007320705,0.000733224],"domain_scores_gemma":[0.9986954,0.0003089385,0.0005403235,0.0002714571,0.0001441009,0.00003974872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01072611,0.005139166,0.001470825,0.00001427473,0.00288943,0.0006317695,0.00384652,0.000362247,0.9296845,0.002233047,0.001093602,0.04190858],"study_design_scores_gemma":[0.007748388,0.006311005,0.9189008,0.0002389228,0.0001064377,0.002388442,0.0009836988,0.000009447926,0.01564875,0.0009703779,0.04607903,0.0006146371],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9774815,0.01714963,0.00002743232,0.002185341,0.002437155,0.0001557127,0.000004440674,0.00002652776,0.000532195],"genre_scores_gemma":[0.9949444,0.003312982,0.0001487652,0.001124087,0.00002468137,0.00000255091,0.000007421761,0.00001390772,0.0004211921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.91743,"threshold_uncertainty_score":0.999987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008256203169700804,"score_gpt":0.2669441183177302,"score_spread":0.2586879151480294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}