{"id":"W1974497193","doi":"10.1111/j.1471-4159.2011.07613.x","title":"The prion protein unstructured N‐terminal region is a broad‐spectrum molecular sensor with diverse and contrasting potential functions","year":2011,"lang":"en","type":"review","venue":"Journal of Neurochemistry","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Neurotoxicity; Extracellular; Prion protein; Function (biology); In vivo; Neurodegeneration; Moiety; In vitro; Broad spectrum; Chemistry; Pathogenesis; Biology; Biochemistry; Cell biology; Biophysics; Disease; Stereochemistry; Medicine; Genetics; Toxicity; Immunology; Combinatorial chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001257171,0.0003870561,0.000557224,0.00005013386,0.0002457474,0.0001012483,0.0003325782,0.0002780799,0.000009836863],"category_scores_gemma":[0.0001200081,0.0002446204,0.0004404341,0.00009247763,0.0001506777,0.000008645557,0.0001434839,0.0005107884,7.642158e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002281799,"about_ca_system_score_gemma":0.0003103675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002347429,"about_ca_topic_score_gemma":4.62454e-7,"domain_scores_codex":[0.9985018,0.0001115361,0.0005192478,0.0003581862,0.0002254078,0.0002838067],"domain_scores_gemma":[0.9981978,0.00001871924,0.001076569,0.0003594774,0.0001483916,0.0001990701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008142153,0.00009653943,0.00002758528,0.003864602,0.001162218,0.001793164,0.00002658184,0.00000387623,0.08273627,0.000008294204,0.0006859883,0.9087807],"study_design_scores_gemma":[0.001337009,0.0008645434,0.00006478406,0.004896648,0.002082376,0.0229834,0.00009452359,0.000006328997,0.008377515,0.00005611846,0.9584777,0.0007590789],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03516931,0.9634199,0.0007434869,0.00007646356,0.0001204014,0.0003960049,0.00002692741,0.000006754237,0.00004072758],"genre_scores_gemma":[0.01664562,0.9824226,0.0001896773,0.00005400502,0.000415142,0.00001668425,0.00001744184,0.00005361851,0.0001852211],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9577917,"threshold_uncertainty_score":0.997533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01409746926744814,"score_gpt":0.2477861154108776,"score_spread":0.2336886461434295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}