{"id":"W1974510733","doi":"10.1371/journal.pone.0067689","title":"Modulation of Higher Order Chromatin Conformation in Mammalian Cell Nuclei Can Be Mediated by Polyamines and Divalent Cations","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Wellcome Trust; Wellcome","keywords":"Chromatin; Divalent; Biophysics; Interphase; Prophase; Chemistry; Spermine; Mitosis; Cell biology; DNA; Biochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003648017,0.00007776437,0.00009880925,0.00003292737,0.00002394738,0.00001030441,0.00005730869,0.00007991045,0.00005275953],"category_scores_gemma":[0.00001660561,0.00007960868,0.00001116799,0.0000590313,0.00003179348,0.000006194287,0.00003508711,0.00003063766,0.000003389867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001248233,"about_ca_system_score_gemma":0.00001743264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003499732,"about_ca_topic_score_gemma":0.0001629617,"domain_scores_codex":[0.9994838,0.0000166741,0.0002066637,0.0001086126,0.00008478278,0.00009943049],"domain_scores_gemma":[0.9996322,0.000006414368,0.0001021525,0.0001336043,0.00008805627,0.00003754532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00000264749,0.0002011743,0.008809743,0.00006798348,0.00001786278,3.858427e-8,0.0001324663,0.0000306918,0.9903408,0.00002055213,0.0002944042,0.00008166145],"study_design_scores_gemma":[0.00139869,0.000231382,0.3387731,0.00004998493,0.00004716603,7.402222e-7,0.0002256694,0.03093892,0.6275517,0.0001258267,0.0003195217,0.0003372255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986416,0.0001231505,0.00003483431,0.0005247213,0.00001222924,0.000232644,0.00008070903,0.000004747607,0.0003453587],"genre_scores_gemma":[0.9970683,0.0001166821,0.001118933,0.00008801051,0.00001626619,0.00002849441,0.000949994,0.00001139878,0.0006018596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.362789,"threshold_uncertainty_score":0.3246348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009386636353812606,"score_gpt":0.1899369037012511,"score_spread":0.1805502673474385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}