{"id":"W1974551148","doi":"10.1007/s10295-005-0033-8","title":"Heterologous production of daptomycin in Streptomyces lividans","year":2005,"lang":"en","type":"article","venue":"Journal of Industrial Microbiology & Biotechnology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Actinorhodin; Daptomycin; Streptomycetaceae; Biology; Streptomyces; Fermentation; Actinomycetales; Heterologous; Biochemistry; Streptomyces coelicolor; Shuttle vector; Gene cluster; Bacillus subtilis; Streptomyces albus; Microbiology; Plasmid; Heterologous expression; Bacteria; Recombinant DNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0007603805,0.000207979,0.0008582266,0.0009228229,0.00003099821,0.000004422123,0.0002742318,0.00135157,0.0001116437],"category_scores_gemma":[0.001022105,0.0001493354,0.0001837984,0.0005133568,0.0004826016,0.00009873368,0.00007898681,0.001325389,0.00001053538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001479735,"about_ca_system_score_gemma":0.0001986311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002682699,"about_ca_topic_score_gemma":0.00005931922,"domain_scores_codex":[0.9980193,0.0001398954,0.001133159,0.0002984588,0.00006882588,0.0003403155],"domain_scores_gemma":[0.9985297,0.00007070546,0.0008477235,0.0002860698,0.000210707,0.00005510676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001009159,0.0003482893,0.004858508,0.00001441121,0.0001234635,0.0000351457,0.00005345537,0.00001190989,0.9390074,0.00003100267,0.003632752,0.05087451],"study_design_scores_gemma":[0.001894286,0.001673714,0.0005808911,0.0002123823,0.00009887351,0.003287266,0.0001045112,0.000001381704,0.9557247,0.00002145418,0.03628289,0.0001177111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.962891,0.001088141,0.000004648515,0.034765,0.0008882651,0.0002992947,0.00001125277,0.00002459335,0.00002783259],"genre_scores_gemma":[0.9969183,0.0004017089,0.001384912,0.0002136343,0.0009403717,4.467217e-7,0.000007030687,0.0000138809,0.0001197244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0507568,"threshold_uncertainty_score":0.9999449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02065882648233529,"score_gpt":0.249078122680214,"score_spread":0.2284192961978787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}