{"id":"W1974580249","doi":"10.1177/1087057113520227","title":"Roles of PKC Isoforms in PMA-Induced Modulation of the hERG Channel (Kv11.1)","year":2014,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital du Sacré-Cœur de Montréal","funders":"","keywords":"Protein kinase C; hERG; Activator (genetics); Cell biology; Chemistry; Voltage clamp; Biophysics; Electrophysiology; Intracellular; Gene isoform; Membrane potential; Biology; Signal transduction; Biochemistry; Neuroscience; Potassium channel; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002245983,0.0002379527,0.0002440531,0.0001038846,0.0001231843,0.0002677441,0.0001466406,0.0001563852,0.001140031],"category_scores_gemma":[0.0002298913,0.00009269545,0.0001987621,0.00012052,0.0001562086,0.0002132146,0.0001752307,0.0005339832,0.0002729526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002200308,"about_ca_system_score_gemma":0.000192667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001921494,"about_ca_topic_score_gemma":0.0002627962,"domain_scores_codex":[0.999837,0.00002852044,0.00001998495,0.00003308104,0.00002537892,0.00005595076],"domain_scores_gemma":[0.9998959,0.00002048219,0.00003705596,0.00001304265,0.00001200799,0.00002146879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005065724,0.00003156067,0.0003009305,0.00004335229,0.000003116869,0.00003569345,0.00001122308,0.00005539255,0.996587,0.00005032744,0.00002077203,0.002354073],"study_design_scores_gemma":[0.00004568833,0.0004876268,0.007934655,0.000009722618,0.00001699725,0.0001558729,0.00002716269,0.0003114641,0.9900932,0.00003805006,0.0008763159,0.000003358515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952196,0.002363462,0.001016919,0.00009618109,0.00004245941,0.00002975573,0.0001267793,0.00002498189,0.001079874],"genre_scores_gemma":[0.9960589,0.001622729,0.001026861,0.00004399117,0.00001122599,0.00003164561,0.00008739933,0.00000684746,0.001110309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001140031,"threshold_uncertainty_score":0.003813803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008236216959327384,"score_gpt":0.2344204366350551,"score_spread":0.2261842196757277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}