{"id":"W1974605151","doi":"10.1098/rstb.2012.0536","title":"Serotonin and beyond: therapeutics for major depression","year":2013,"lang":"en","type":"review","venue":"Philosophical Transactions of the Royal Society B Biological Sciences","topic":"Treatment of Major Depression","field":"Medicine","cited_by":254,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Ottawa Mental Health Centre; University of Ottawa","funders":"","keywords":"Monoaminergic; Antidepressant; Serotonin; Dopamine; Norepinephrine; Major depressive disorder; Mechanism of action; Medicine; Reuptake; Neuroscience; Psychology; Pharmacology; Psychiatry; Internal medicine; Receptor; Biology; Hippocampus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003840119,0.0003806731,0.001141152,0.00003275225,0.000595052,0.00003343884,0.0004619913,0.0007034033,0.0001107138],"category_scores_gemma":[0.00004691367,0.0001582989,0.001458343,0.0003057534,0.001511683,0.00004910644,0.00007028817,0.0005032672,0.000004778578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005739065,"about_ca_system_score_gemma":0.000127891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001254327,"about_ca_topic_score_gemma":2.050972e-7,"domain_scores_codex":[0.9980131,0.0001591169,0.0005065748,0.0006156883,0.0003724325,0.0003330861],"domain_scores_gemma":[0.9984468,0.0007426987,0.0002765,0.0003219393,0.00006287097,0.0001491426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003577702,0.0005438284,0.0003029495,0.002729393,0.0004504047,4.045612e-7,0.00003755614,0.000005590595,0.00003846767,0.0003517928,0.00009992156,0.9954039],"study_design_scores_gemma":[0.005904801,0.007776872,0.002038498,0.02027438,0.01659803,0.0002284043,0.000217665,0.004648359,0.0007877716,0.06983912,0.8691989,0.002487237],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005949626,0.9910315,0.001085566,0.003634418,0.000186535,0.002968989,0.000108851,0.00006700488,0.0003221794],"genre_scores_gemma":[0.01034059,0.9809183,0.007534419,0.0002904695,0.000154361,0.0005378985,0.00001453577,0.00002147921,0.0001879558],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9929167,"threshold_uncertainty_score":0.6455242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1474588424834951,"score_gpt":0.3720070666993534,"score_spread":0.2245482242158582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}