{"id":"W1974623973","doi":"10.1038/cddis.2014.391","title":"Gefitinib targets ZAP-70-expressing chronic lymphocytic leukemia cells and inhibits B-cell receptor signaling","year":2014,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research Manitoba; University of Manitoba","funders":"CancerCare Manitoba Foundation; CLL Global Research Foundation","keywords":"Gefitinib; Syk; Chronic lymphocytic leukemia; Cancer research; Tyrosine kinase; Protein kinase B; Bruton's tyrosine kinase; Viability assay; breakpoint cluster region; Apoptosis; Signal transduction; Leukemia; Biology; Medicine; Immunology; Epidermal growth factor receptor; Receptor; Internal medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004442953,0.0004006917,0.0004820424,0.0001634382,0.0002869836,0.0001488756,0.0001639773,0.0002060496,0.0004361124],"category_scores_gemma":[0.0003398969,0.0003585213,0.0001256784,0.0001640912,0.0002303583,0.0001702258,0.0002495061,0.0002911017,0.0001979542],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.01024062,"about_ca_system_score_gemma":0.01928122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002155163,"about_ca_topic_score_gemma":0.000002862685,"domain_scores_codex":[0.9970597,0.0001250541,0.0004252676,0.0008263622,0.0006974628,0.0008661404],"domain_scores_gemma":[0.996248,0.0003326992,0.0001197272,0.0005466028,0.0001147614,0.002638189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004128141,0.0006445362,0.004039036,0.01822988,0.0001572444,0.001859267,0.001411247,0.001919643,0.915643,0.000470138,0.01981013,0.03168771],"study_design_scores_gemma":[0.06784095,0.0007842292,0.000437769,0.001865674,0.0005593271,0.0001334398,0.0001809554,0.3406509,0.5587679,0.0005024489,0.0269305,0.001345973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784122,0.01434919,0.0003575487,0.00007143537,0.0001612429,0.0005722976,0.00002881821,0.000131852,0.005915462],"genre_scores_gemma":[0.9932901,0.001290988,0.0004940195,0.0007772483,0.0006150107,0.00003963349,0.00008107674,0.00008197962,0.003329998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3568752,"threshold_uncertainty_score":0.9998867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0122857229256854,"score_gpt":0.2464462637791457,"score_spread":0.2341605408534603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}