{"id":"W1974623973","doi":"10.1038/cddis.2014.391","title":"Gefitinib targets ZAP-70-expressing chronic lymphocytic leukemia cells and inhibits B-cell receptor signaling","year":2014,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research Manitoba; University of Manitoba","funders":"CancerCare Manitoba Foundation; CLL Global Research Foundation","keywords":"Gefitinib; Syk; Chronic lymphocytic leukemia; Cancer research; Tyrosine kinase; Protein kinase B; Bruton's tyrosine kinase; Viability assay; breakpoint cluster region; Apoptosis; Signal transduction; Leukemia; Biology; Medicine; Immunology; Epidermal growth factor receptor; Receptor; Internal medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009725747,0.0003072922,0.0004711715,0.0002052847,0.0001484695,0.0003411345,0.0001651339,0.0002683132,0.0008877364],"category_scores_gemma":[0.00008371457,0.00007944208,0.0002647561,0.0001334489,0.0001149151,0.000129695,0.0001082535,0.0003892677,0.0004326457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003723194,"about_ca_system_score_gemma":0.0002100717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007304425,"about_ca_topic_score_gemma":0.001331145,"domain_scores_codex":[0.9998883,0.00001258384,0.000008991976,0.00001598553,0.00002448784,0.00004979282],"domain_scores_gemma":[0.9999675,0.000006527742,0.000007346536,0.000003525323,0.000004499241,0.00001052787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003190779,0.0001610518,0.0007086725,0.0001819296,0.00002334264,0.0001384739,0.0000206728,0.0003654361,0.9839691,0.0001388521,0.0005764531,0.013397],"study_design_scores_gemma":[0.0001916138,0.003118664,0.01635432,0.00002094894,0.00005626172,0.002162537,0.00003823399,0.001659258,0.9577985,0.0001053657,0.01847674,0.00001752728],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986316,0.008115267,0.001498168,0.0001741663,0.00007458982,0.00006044259,0.0005131485,0.0002092145,0.003039026],"genre_scores_gemma":[0.9941149,0.002721819,0.0007978218,0.00007122935,0.00002420639,0.00004582346,0.0007402155,0.000009988516,0.001474074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008877364,"threshold_uncertainty_score":0.002969742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0122857229256854,"score_gpt":0.2464462637791457,"score_spread":0.2341605408534603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}