{"id":"W1974625077","doi":"10.1038/nature11213","title":"Novel mutations target distinct subgroups of medulloblastoma","year":2012,"lang":"en","type":"article","venue":"Nature","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":853,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Cancer Institute; National Institutes of Health; American Lebanese Syrian Associated Charities; CERN","keywords":"Medulloblastoma; Biology; Wnt signaling pathway; Carcinogenesis; Epigenetics; Genetics; Gene; Cancer research; Mutation; Lineage (genetic); Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007627645,0.00007079953,0.00007220456,0.0000148829,0.00002990536,0.000003254419,0.00008380793,0.0004367354,0.00003446438],"category_scores_gemma":[0.00007208618,0.00006188974,0.00005822951,0.00005724573,0.0000329075,0.000002282281,0.00002973982,0.000242663,0.000003724788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007249462,"about_ca_system_score_gemma":0.0000298027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006352485,"about_ca_topic_score_gemma":0.000008882464,"domain_scores_codex":[0.9995613,0.000009186329,0.00009652995,0.0001018934,0.00009633587,0.0001348049],"domain_scores_gemma":[0.999674,0.000006727198,0.00004929164,0.0001577852,0.0000633521,0.00004884047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002676398,0.0001133651,0.006394536,0.00002913642,0.00003756704,1.639261e-7,0.00009002366,0.0001114157,0.987253,0.0003655484,0.004678402,0.0009000517],"study_design_scores_gemma":[0.0007939321,0.00011572,0.03884571,0.00003122847,0.00004136073,0.00004222628,0.0001200319,0.0004621317,0.8769854,0.000169572,0.0820974,0.0002952736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897082,0.003155014,0.004549388,0.0001085687,0.0002830128,0.00005422161,0.00007011305,0.000009937258,0.002061523],"genre_scores_gemma":[0.9946418,0.000009791014,0.004366432,0.0001498064,0.000338459,0.000005160731,0.0001658942,0.00001118707,0.000311474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1102676,"threshold_uncertainty_score":0.3368503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006626444582552253,"score_gpt":0.2615397797656388,"score_spread":0.2549133351830866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}