{"id":"W1974634612","doi":"10.1371/journal.pone.0085768","title":"Human Variants in the Neuronal Basic Helix-Loop-Helix/Per-Arnt-Sim (bHLH/PAS) Transcription Factor Complex NPAS4/ARNT2 Disrupt Function","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Australian Research Council; McGill University","keywords":"Aryl hydrocarbon receptor nuclear translocator; PAS domain; Transcription factor; Biology; Cell biology; Reporter gene; Gene expression; Biochemistry; Gene; Aryl hydrocarbon receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002102951,0.00094692,0.000533112,0.0003993077,0.0002464628,0.0002710913,0.0004246208,0.0008006953,0.002993703],"category_scores_gemma":[0.0003232534,0.000218339,0.0007415328,0.0003091611,0.0006272777,0.0001560408,0.000371568,0.0007226308,0.0007435771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004583144,"about_ca_system_score_gemma":0.0002439177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001392054,"about_ca_topic_score_gemma":0.001810158,"domain_scores_codex":[0.9995837,0.00008120498,0.00006345915,0.000115881,0.000110062,0.00004559559],"domain_scores_gemma":[0.9997666,0.00007051174,0.0000824306,0.00002243321,0.00001319759,0.00004465786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00037952,0.00009185562,0.001966306,0.00006092241,0.0001257625,0.003401846,0.00007907779,0.0004990423,0.9894091,0.0003499419,0.0001965385,0.003440092],"study_design_scores_gemma":[0.000305157,0.001539287,0.04868612,0.00004685781,0.000397341,0.04180723,0.0002502814,0.007287657,0.8868186,0.000757757,0.01201607,0.0000875759],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916012,0.0006627777,0.005595068,0.0001458687,0.0000686503,0.00007037367,0.000894706,0.0001681112,0.0007933474],"genre_scores_gemma":[0.995447,0.000191006,0.002533103,0.00008468034,0.000015898,0.00002623152,0.000583261,0.00008250749,0.001036236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002993703,"threshold_uncertainty_score":0.01001495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04713409805643281,"score_gpt":0.229112557516454,"score_spread":0.1819784594600212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}