{"id":"W1974672059","doi":"10.1016/j.str.2008.12.023","title":"Kinase Domain Insertions Define Distinct Roles of CLK Kinases in SR Protein Phosphorylation","year":2009,"lang":"en","type":"article","venue":"Structure","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Ontario Genomics; National Institutes of Health; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Canadian Institutes of Health Research; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust","keywords":"SR protein; RNA splicing; Phosphorylation; Kinase; Alternative splicing; Splicing factor; Biology; Protein-Serine-Threonine Kinases; Cyclin-dependent kinase 1; Serine; Biochemistry; Cell biology; Protein kinase A; Gene isoform; Gene; Cell cycle; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001671549,0.0003357106,0.0002686032,0.0001652382,0.0001313735,0.0003143022,0.000312142,0.00028886,0.001273695],"category_scores_gemma":[0.0001795273,0.0001718251,0.0003176299,0.0001442479,0.0002663463,0.0002766905,0.0002847407,0.0005067709,0.0005119467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003766487,"about_ca_system_score_gemma":0.0002153819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002673227,"about_ca_topic_score_gemma":0.000413121,"domain_scores_codex":[0.9998957,0.00001540736,0.00001407077,0.00002469214,0.00002514925,0.00002495087],"domain_scores_gemma":[0.9998391,0.00003999205,0.0000503634,0.00002027371,0.00001159876,0.00003871788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004183304,0.00002843982,0.000451729,0.00003373958,0.000007846635,0.0001447908,0.00001874188,0.0002727533,0.9958912,0.0006187214,0.00002751452,0.002086098],"study_design_scores_gemma":[0.00009635529,0.0001918366,0.006558055,0.00001066826,0.00002844771,0.001107223,0.00003390631,0.00177336,0.9872915,0.0003408075,0.002554339,0.00001344261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948142,0.0006586569,0.002700309,0.00004417555,0.00001202721,0.00002540413,0.000188602,0.00004443927,0.001512393],"genre_scores_gemma":[0.9954473,0.0002582902,0.003264783,0.00006621527,0.000003973344,0.00002100198,0.0003487409,0.00002528177,0.0005643805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001273695,"threshold_uncertainty_score":0.004260898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005716144802763117,"score_gpt":0.2483527387283362,"score_spread":0.2426365939255731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}