{"id":"W1974694449","doi":"10.1021/jm058167w","title":"Design and Studies of Novel 5-Substituted Alkynylpyrimidine Nucleosides as Potent Inhibitors of Mycobacteria","year":2005,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Antimycobacterial; Chemistry; Bicyclic molecule; Pyrimidine; Stereochemistry; Mycobacterium tuberculosis; Tuberculosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001644909,0.0003400782,0.0003393607,0.0001239744,0.0001061474,0.0002407833,0.0003230134,0.0002583991,0.0008503117],"category_scores_gemma":[0.0001194953,0.0001446384,0.000170597,0.0001216658,0.0001357981,0.000215842,0.0001554868,0.0003496974,0.0002917153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002361329,"about_ca_system_score_gemma":0.0002698509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003412284,"about_ca_topic_score_gemma":0.000762296,"domain_scores_codex":[0.9999137,0.00001559429,0.00001016753,0.00001774745,0.00002183369,0.00002097662],"domain_scores_gemma":[0.9999408,0.000007373707,0.00001776991,0.000005627566,0.00001198286,0.00001640702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001978783,0.0001326241,0.0003643237,0.000227251,0.00001609025,0.0002060851,0.00004395037,0.001306804,0.9851505,0.0006585886,0.00008403846,0.01161188],"study_design_scores_gemma":[0.0001721068,0.004896081,0.002093884,0.00003213411,0.00007764691,0.0006485897,0.00003005354,0.002066658,0.970358,0.0001381559,0.01946721,0.00001957008],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9763837,0.01222461,0.007062677,0.0001020682,0.00006394266,0.0002457446,0.0003258979,0.00006622318,0.003525077],"genre_scores_gemma":[0.9694229,0.009029828,0.01712321,0.000118622,0.00003716451,0.0001768923,0.0007406517,0.00001969272,0.003330986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008503117,"threshold_uncertainty_score":0.002844632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0663880817291105,"score_gpt":0.3650347085110531,"score_spread":0.2986466267819426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}