{"id":"W1974754565","doi":"10.1371/journal.pbio.1001809","title":"A Functional Screen Reveals an Extensive Layer of Transcriptional and Splicing Control Underlying RAS/MAPK Signaling in Drosophila","year":2014,"lang":"en","type":"article","venue":"PLoS Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Biology; Drosophila (subgenus); RNA splicing; Alternative splicing; Cell biology; MAPK/ERK pathway; Signal transduction; Genetics; Drosophila melanogaster; Computational biology; Evolutionary biology; Gene; Exon; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004079651,0.0001202662,0.0002379392,0.00009515689,0.00006338573,0.000009156678,0.00009448213,0.0001619717,0.00001830619],"category_scores_gemma":[0.000167465,0.0001098322,0.0000484267,0.00005984852,0.0001276984,0.000007352686,0.0000300866,0.0001244059,0.00000175462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009559613,"about_ca_system_score_gemma":0.00003635833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008930983,"about_ca_topic_score_gemma":0.00006711149,"domain_scores_codex":[0.9988331,0.0002145479,0.0002477585,0.0003429377,0.00008947973,0.0002722408],"domain_scores_gemma":[0.9994911,0.00009057835,0.00006799821,0.0001452104,0.0001148496,0.00009029701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002558442,0.00004775334,0.02510925,0.00001911479,0.00004714773,0.000001216892,0.00002268817,0.0001356216,0.9718643,0.001819935,0.00001181482,0.000665281],"study_design_scores_gemma":[0.008595363,0.003545723,0.3651122,0.000212469,0.00007719867,0.00007383958,0.0003292858,0.01193985,0.6010634,0.00785284,0.0004489047,0.0007488337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929714,0.0003527511,0.006112305,0.0002099868,0.00002994837,0.0001670812,0.00002461845,0.000006265637,0.0001256635],"genre_scores_gemma":[0.9986825,0.0000365532,0.0004852664,0.0004393807,0.0001542298,0.00001652307,0.0001072104,0.00001341629,0.00006490634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3708009,"threshold_uncertainty_score":0.4478828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04863267720669005,"score_gpt":0.2928164472594527,"score_spread":0.2441837700527627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}