{"id":"W1974790023","doi":"10.1016/j.neuroscience.2003.11.009","title":"Striatal phosphodiesterase mRNA and protein levels are reduced in Huntington′s disease transgenic mice prior to the onset of motor symptoms","year":2004,"lang":"en","type":"article","venue":"Neuroscience","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":174,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"National Institute of Mental Health","keywords":"Huntington's disease; Phosphodiesterase; Huntingtin; Internal medicine; Striatum; Endocrinology; Genetically modified mouse; Biology; Neurodegeneration; Transgene; Messenger RNA; Medicine; Gene; Disease; Genetics; Dopamine; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001416336,0.000109122,0.0000924327,0.0000425343,0.000102661,0.00003003658,0.0001754335,0.00003825347,0.000001748181],"category_scores_gemma":[0.0001978939,0.00008331472,0.00003837219,0.0001961429,0.0001394715,0.00001208898,0.00006626786,0.00006208222,0.000001042312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001311091,"about_ca_system_score_gemma":0.0001070225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002600455,"about_ca_topic_score_gemma":0.0000606611,"domain_scores_codex":[0.999102,0.00004106868,0.0001800495,0.0003522619,0.0001505701,0.0001740419],"domain_scores_gemma":[0.9995377,0.000007316162,0.00007974511,0.0002345997,0.00003471419,0.0001059256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001971952,0.00005902808,0.003537537,0.00001797443,0.000001330391,9.329018e-7,0.0001179455,0.0004179152,0.99507,0.00001372084,0.00001495233,0.0005515133],"study_design_scores_gemma":[0.0005850571,0.0001791795,0.3996166,0.00005069204,0.000005179294,0.000002395246,0.00003269634,0.00003653507,0.5984021,0.00001698989,0.0009699822,0.0001026054],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978686,0.00006981154,0.0003004915,0.0009657115,0.0002146324,0.0004996865,0.0000663367,0.000007131866,0.000007602852],"genre_scores_gemma":[0.9990748,0.00001036921,0.00009178343,0.0005306703,0.00003709923,0.00003626212,0.000004690444,0.000008168566,0.000206203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3966678,"threshold_uncertainty_score":0.3397475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01364253601145433,"score_gpt":0.2455840972528129,"score_spread":0.2319415612413586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}