{"id":"W1974798136","doi":"10.1038/nature10825","title":"Clonal selection drives genetic divergence of metastatic medulloblastoma","year":2012,"lang":"en","type":"article","venue":"Nature","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":412,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; University of Toronto; University Health Network; SickKids Foundation; McGill University and Génome Québec Innovation Centre; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; National Institute of Neurological Disorders and Stroke; Brain Tumour Charity; National Cancer Institute; Sontag Foundation","keywords":"Medulloblastoma; Spinal cord; Cerebrospinal fluid; Medicine; Cancer research; Chemotherapy; Pathology; Radiation therapy; Central nervous system; Biology; Oncology; Internal medicine; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001071973,0.0001074749,0.0001148054,0.00003374051,0.00005293011,0.00000323714,0.0001094319,0.0003056401,0.00002826859],"category_scores_gemma":[0.0001376481,0.00009464387,0.00006716526,0.0001131263,0.0000619328,0.000003136409,0.00006844813,0.0002839449,0.000008665469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007781139,"about_ca_system_score_gemma":0.00003166984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003400912,"about_ca_topic_score_gemma":0.000009702464,"domain_scores_codex":[0.9993068,0.00004908461,0.0001287873,0.0001550883,0.0001543506,0.0002058995],"domain_scores_gemma":[0.9996361,0.00001322567,0.00006850467,0.0001201265,0.0001051063,0.00005698685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002961281,0.0000679906,0.0675442,0.00003076202,0.0001219691,7.014963e-7,0.0001496519,0.0000636642,0.9284003,0.0001073513,0.002460335,0.001023446],"study_design_scores_gemma":[0.0001968544,0.0001718277,0.1265205,0.00001234742,0.00005034105,0.00002205728,0.00007616907,0.00002760962,0.8567284,0.00004543002,0.01599511,0.0001533445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902063,0.008215364,0.0008936755,0.00004891384,0.0003131703,0.00008165465,0.00001754638,0.0000098533,0.000213519],"genre_scores_gemma":[0.9951799,0.0001029292,0.004084822,0.0001386236,0.000260604,0.000008703985,0.00001669753,0.00001198403,0.0001957251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07167196,"threshold_uncertainty_score":0.3859465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008703539665393296,"score_gpt":0.2663141315946079,"score_spread":0.2576105919292146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}