{"id":"W1974798136","doi":"10.1038/nature10825","title":"Clonal selection drives genetic divergence of metastatic medulloblastoma","year":2012,"lang":"en","type":"article","venue":"Nature","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":412,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; University of Toronto; University Health Network; SickKids Foundation; McGill University and Génome Québec Innovation Centre; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; National Institute of Neurological Disorders and Stroke; Brain Tumour Charity; National Cancer Institute; Sontag Foundation","keywords":"Medulloblastoma; Spinal cord; Cerebrospinal fluid; Medicine; Cancer research; Chemotherapy; Pathology; Radiation therapy; Central nervous system; Biology; Oncology; Internal medicine; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001291174,0.0001417606,0.0001794725,0.0003606533,0.0002372746,0.0003435569,0.0002899653,0.0002211505,0.001608803],"category_scores_gemma":[0.000235344,0.0001660315,0.0001333864,0.0002131951,0.0002169412,0.0001811379,0.0003913153,0.0006169589,0.0003323456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005013217,"about_ca_system_score_gemma":0.0001954049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001420454,"about_ca_topic_score_gemma":0.003080214,"domain_scores_codex":[0.9998462,0.00002165135,0.00001048665,0.00002470239,0.0000646014,0.00003233142],"domain_scores_gemma":[0.9997999,0.00006520337,0.00003480111,0.00002976759,0.0000227338,0.00004754792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004142021,0.0000114381,0.0005106412,0.000004266741,0.000002627057,0.00008281669,0.00001658586,0.00007359809,0.9980527,0.000474282,0.00003519568,0.0006944885],"study_design_scores_gemma":[0.00001708913,0.0001809119,0.02605632,0.000003101258,0.00001297684,0.001494965,0.0001004443,0.003149949,0.9655097,0.0002813197,0.003186811,0.000006477665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971707,0.000156827,0.0008213942,0.00004495354,0.000006193141,0.000008226076,0.0001165625,0.00002831183,0.001646846],"genre_scores_gemma":[0.9975631,0.0000901248,0.0004871181,0.00002299781,0.000003281139,0.000007722428,0.0001605801,0.00002752179,0.001637442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001608803,"threshold_uncertainty_score":0.005381942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008703539665393296,"score_gpt":0.2663141315946079,"score_spread":0.2576105919292146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}