{"id":"W1974822561","doi":"10.1016/j.ejpb.2007.08.011","title":"A novel liposomal irinotecan formulation with significant anti-tumour activity: Use of the divalent cation ionophore A23187 and copper-containing liposomes to improve drug retention","year":2007,"lang":"en","type":"article","venue":"European Journal of Pharmaceutics and Biopharmaceutics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Chemistry; Irinotecan; Ionophore; Liposome; Divalent; Pharmacology; Chromatography; Membrane; Biochemistry; Internal medicine; Organic chemistry; Medicine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001051614,0.0002217292,0.0002172421,0.0001177743,0.00014171,0.0000743938,0.0001697939,0.00004587719,0.000001480895],"category_scores_gemma":[0.00002798447,0.0001597148,0.00009255829,0.0001617843,0.00009066616,0.00002970732,0.0001715529,0.0002568872,2.400001e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003626222,"about_ca_system_score_gemma":0.00007911764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000954292,"about_ca_topic_score_gemma":0.00001086404,"domain_scores_codex":[0.9986206,0.0001111256,0.00046131,0.0002482597,0.0002905476,0.0002681176],"domain_scores_gemma":[0.998677,0.00003114078,0.0005628493,0.0001763171,0.0003226636,0.0002300486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009773502,0.0001171924,0.002046423,0.0000487639,0.0001356263,0.000009875304,0.0005314712,0.0002675398,0.9533147,0.00003720847,0.00001031181,0.04250357],"study_design_scores_gemma":[0.002071465,0.001008422,0.01936611,0.00009506958,0.0002760878,0.0001157698,0.0002578773,0.001014508,0.966001,0.000004055521,0.009566928,0.0002227318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910995,0.0005984108,0.006997622,0.0005022106,0.0003914183,0.0003457052,0.00003758067,0.000004983536,0.00002261481],"genre_scores_gemma":[0.9962696,0.001455184,0.001478989,0.0004312341,0.0002761004,0.00000113306,0.000004727891,0.00004039423,0.00004258287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04228084,"threshold_uncertainty_score":0.651298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04165812691902265,"score_gpt":0.2896601416503658,"score_spread":0.2480020147313431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}