{"id":"W1974822561","doi":"10.1016/j.ejpb.2007.08.011","title":"A novel liposomal irinotecan formulation with significant anti-tumour activity: Use of the divalent cation ionophore A23187 and copper-containing liposomes to improve drug retention","year":2007,"lang":"en","type":"article","venue":"European Journal of Pharmaceutics and Biopharmaceutics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Chemistry; Irinotecan; Ionophore; Liposome; Divalent; Pharmacology; Chromatography; Membrane; Biochemistry; Internal medicine; Organic chemistry; Medicine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001226259,0.000324689,0.000322529,0.000141374,0.0001449174,0.0002783145,0.000333792,0.0003198677,0.0009647332],"category_scores_gemma":[0.0001207492,0.000149707,0.0001216523,0.0001151322,0.0002231845,0.0003539508,0.0001749489,0.0005000765,0.0003142875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004200103,"about_ca_system_score_gemma":0.0003019831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005460376,"about_ca_topic_score_gemma":0.0006718474,"domain_scores_codex":[0.9999413,0.000008199301,0.000006022525,0.00001456113,0.00001699061,0.00001279351],"domain_scores_gemma":[0.9999368,0.000009399229,0.00001799188,0.000005672352,0.00000958263,0.0000205387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002050773,0.00005721214,0.00002743051,0.00006617801,0.000005385114,0.0001004946,0.00001322465,0.000107583,0.9941835,0.0001427926,0.00009166728,0.004999613],"study_design_scores_gemma":[0.00007952988,0.0004194902,0.0002897907,0.000002558684,0.00001680988,0.0002983869,0.000005501615,0.0005655485,0.9958442,0.00001881679,0.002453575,0.000005745762],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745356,0.003171592,0.01906916,0.0004276107,0.00008948726,0.0001670061,0.00019899,0.0003090134,0.002031524],"genre_scores_gemma":[0.9823338,0.001185511,0.01259232,0.00009840081,0.00003270009,0.00007467529,0.0002277899,0.0000475858,0.003407243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009647332,"threshold_uncertainty_score":0.003227353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04165812691902265,"score_gpt":0.2896601416503658,"score_spread":0.2480020147313431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}