{"id":"W1974829941","doi":"10.1158/0008-5472.sabcs-09-6096","title":"A Phase (Ph) I/II Study of CR011-VcMMAE, an Antibody-Drug Conjugate, in Patients (Pts) with Locally Advanced or Metastatic Breast Cancer (MBC).","year":2009,"lang":"en","type":"article","venue":"Cancer Research","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Medicine; Metastatic breast cancer; Taxane; Internal medicine; Gastroenterology; Breast cancer; Anthracycline; Phases of clinical research; Clinical endpoint; Capecitabine; Chemotherapy; Progressive disease; Cancer; Surgery; Urology; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009729276,0.001146343,0.001182848,0.0003475026,0.000262794,0.0006322393,0.0007158543,0.0008027235,0.003435247],"category_scores_gemma":[0.0006924645,0.000493005,0.0007594711,0.0003062063,0.0005710098,0.0004725271,0.0003311429,0.002127303,0.0006513119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007920823,"about_ca_system_score_gemma":0.001066059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001210994,"about_ca_topic_score_gemma":0.002220337,"domain_scores_codex":[0.9997013,0.0001463925,0.0000117561,0.0000479494,0.00002458573,0.00006798009],"domain_scores_gemma":[0.9995844,0.0000676177,0.00007823963,0.00003664137,0.00002843744,0.0002046578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6987813,0.07701911,0.007471679,0.000824815,0.0006760172,0.000235816,0.0003037773,0.003717338,0.1131312,0.0003882082,0.003985705,0.0934651],"study_design_scores_gemma":[0.414828,0.5659436,0.009131736,0.00001919202,0.000220114,0.0001865779,0.0000354426,0.001020841,0.006265057,0.00009110146,0.00224196,0.00001647652],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924487,0.0007847642,0.0005764943,0.0002066492,0.00006665615,0.003184676,0.0007293259,0.00008965187,0.001913124],"genre_scores_gemma":[0.9909089,0.0007729738,0.001472009,0.0004431472,0.0001086998,0.002164216,0.001424518,0.00002722248,0.002678207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003435247,"threshold_uncertainty_score":0.01149207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0804814699381781,"score_gpt":0.5015973090577689,"score_spread":0.4211158391195908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}