{"id":"W1974829941","doi":"10.1158/0008-5472.sabcs-09-6096","title":"A Phase (Ph) I/II Study of CR011-VcMMAE, an Antibody-Drug Conjugate, in Patients (Pts) with Locally Advanced or Metastatic Breast Cancer (MBC).","year":2009,"lang":"en","type":"article","venue":"Cancer Research","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Medicine; Metastatic breast cancer; Taxane; Internal medicine; Gastroenterology; Breast cancer; Anthracycline; Phases of clinical research; Clinical endpoint; Capecitabine; Chemotherapy; Progressive disease; Cancer; Surgery; Urology; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003868344,0.0001981487,0.0004610278,0.0001570588,0.0001581818,0.0000191061,0.0002686363,0.00004244633,0.0005591062],"category_scores_gemma":[0.00005049864,0.0001411704,0.00003237577,0.001182968,0.0002352584,0.0001827086,0.00004668369,0.0006021803,0.000004500501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002897424,"about_ca_system_score_gemma":0.0006449869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006481027,"about_ca_topic_score_gemma":0.0004019747,"domain_scores_codex":[0.9975655,0.0001312184,0.000409843,0.0005177762,0.0008334062,0.0005422651],"domain_scores_gemma":[0.9982561,0.0000824856,0.0000846248,0.000506457,0.000664158,0.0004061016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.06102252,0.09067211,0.06468117,0.001181249,0.0005039884,0.0004286295,0.004619736,0.001032876,0.5988319,0.0001073936,0.001486469,0.175432],"study_design_scores_gemma":[0.2535639,0.058915,0.2939955,0.003727036,0.0008356217,0.00009583672,0.008530864,0.003134485,0.3704711,0.0002594678,0.004753757,0.001717477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959715,0.0002190256,0.00001531921,0.001213815,0.00001734658,0.00206385,0.0001633799,0.00002864869,0.0003071184],"genre_scores_gemma":[0.9982348,0.0001691479,0.0001022415,0.0001887074,0.00006928395,0.0005228714,0.0000475963,0.00002744372,0.0006378983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2293143,"threshold_uncertainty_score":0.6121821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0804814699381781,"score_gpt":0.5015973090577689,"score_spread":0.4211158391195908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}