{"id":"W1974844459","doi":"10.1371/journal.ppat.1002691","title":"Nitazoxanide Stimulates Autophagy and Inhibits mTORC1 Signaling and Intracellular Proliferation of Mycobacterium tuberculosis","year":2012,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; British Columbia Centre for Disease Control; University of British Columbia","keywords":"Nitazoxanide; Autophagy; Mycobacterium tuberculosis; mTORC1; Biology; Phagosome; Lysosome; Tuberculosis; Microbiology; Cell biology; Signal transduction; PI3K/AKT/mTOR pathway; Intracellular; Immunology; Medicine; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001620924,0.0001631093,0.0003002376,0.00008595682,0.00006663923,0.00001492662,0.00002500409,0.0001058947,0.00009289588],"category_scores_gemma":[0.00007512495,0.0001407845,0.00004852158,0.00009242928,0.00006736453,0.0001732119,0.000032425,0.000100355,0.000007955843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002028177,"about_ca_system_score_gemma":0.00003031501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004693564,"about_ca_topic_score_gemma":3.806924e-7,"domain_scores_codex":[0.999061,0.00005266937,0.0002667445,0.0001886529,0.0001834493,0.0002474438],"domain_scores_gemma":[0.9993683,0.00006528423,0.00008499426,0.00016314,0.00009008982,0.0002282284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009133235,0.0002615737,0.09933759,0.0002517749,0.0001412807,0.00001151912,0.00118111,0.000004544398,0.8974272,0.0001459968,0.000006908928,0.001139177],"study_design_scores_gemma":[0.0008464871,0.0002160962,0.08512698,0.00014369,0.0003919431,0.00003943693,0.0001302401,0.001103424,0.9116727,0.0001329628,0.00004457763,0.0001514365],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942884,0.004961279,0.00008781117,0.00007496921,0.00004998301,0.0003795527,0.00003070542,0.00005257694,0.0000747607],"genre_scores_gemma":[0.9985252,0.0002185349,0.0007099158,0.0001566425,0.0002638382,0.00002043953,0.00003852812,0.0000289373,0.00003795329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01424553,"threshold_uncertainty_score":0.5741026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01568486065871643,"score_gpt":0.2435039758849041,"score_spread":0.2278191152261877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}