{"id":"W1974874807","doi":"10.1139/o07-058","title":"Expression of the selectable marker gene <i>bsrm</i> in BALB/MK cells induces apoptosis by overproduction of hydrogen peroxide","year":2007,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Narodowa Agencja Wymiany Akademickiej; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Apoptosis; Molecular biology; Hydrogen peroxide; Catalase; Programmed cell death; Cell culture; Chemistry; Biology; Biochemistry; Enzyme; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001355956,0.0003957121,0.0001812409,0.000205855,0.0001421871,0.0002445609,0.0002661328,0.0002171219,0.001193046],"category_scores_gemma":[0.00008867014,0.0001912345,0.000242475,0.0001653439,0.0002311738,0.0001567981,0.000203983,0.0007333527,0.0007376352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000373851,"about_ca_system_score_gemma":0.0001694738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000536776,"about_ca_topic_score_gemma":0.0006784552,"domain_scores_codex":[0.9998299,0.00002335797,0.00002210227,0.00003277126,0.00004999151,0.00004192879],"domain_scores_gemma":[0.9998572,0.0000203227,0.00005091786,0.0000272994,0.000009690479,0.00003457035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003123181,0.000006675789,0.00004968162,0.000006510667,8.331937e-7,0.00001902372,0.000004321697,0.00001172782,0.9996868,0.00003568983,0.000005837939,0.0001416878],"study_design_scores_gemma":[0.00000780766,0.00009432582,0.001232735,0.000002568748,0.000004627523,0.0001401822,0.000008169593,0.0002175933,0.9974516,0.00001465318,0.0008239348,0.000001834281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937004,0.0005211644,0.004006831,0.00005712613,0.000023029,0.00002996452,0.0004120505,0.0001107029,0.00113886],"genre_scores_gemma":[0.9902345,0.0004746009,0.004902717,0.00002704879,0.000008559663,0.00003220577,0.000881348,0.0000420064,0.003396971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001193046,"threshold_uncertainty_score":0.003991127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003825110298605021,"score_gpt":0.1876421761287201,"score_spread":0.1838170658301151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}