{"id":"W1974903221","doi":"10.1056/nejmoa1311107","title":"Ceritinib in <i>ALK</i> -Rearranged Non–Small-Cell Lung Cancer","year":2014,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":1475,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute","keywords":"Ceritinib; Crizotinib; Anaplastic lymphoma kinase; Medicine; ALK inhibitor; Internal medicine; Lung cancer; Oncology; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000818208,0.0003865642,0.0009724481,0.0001769309,0.0002308421,0.0002979391,0.0003080434,0.0002975846,0.0005401591],"category_scores_gemma":[0.0005810531,0.0001068424,0.0003733684,0.0002052531,0.0002371713,0.0002486084,0.0002153657,0.0006827722,0.0001643165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008948726,"about_ca_system_score_gemma":0.000804918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001279116,"about_ca_topic_score_gemma":0.003265674,"domain_scores_codex":[0.9997392,0.0001019084,0.0000270821,0.00004598183,0.00003942156,0.00004631225],"domain_scores_gemma":[0.9996356,0.0001009669,0.0000856184,0.00001719888,0.00003594904,0.0001247066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1155675,0.006498623,0.1739369,0.001680754,0.001011082,0.004356036,0.0004553849,0.01023001,0.1445909,0.0003849881,0.008303534,0.5329844],"study_design_scores_gemma":[0.06037739,0.2298332,0.5534681,0.0002202778,0.001919038,0.01593527,0.0002843324,0.01620309,0.08820224,0.0005741931,0.03288787,0.00009513358],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913397,0.006768006,0.0003376047,0.0003173206,0.00003966071,0.0001257955,0.00006196656,0.00003446446,0.000975445],"genre_scores_gemma":[0.9976197,0.001510651,0.0003042337,0.0001126249,0.00005132661,0.00003670072,0.0001520467,0.000005201021,0.0002073485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001279116,"threshold_uncertainty_score":0.006492794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01245342306717361,"score_gpt":0.3153880680622122,"score_spread":0.3029346449950386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}