{"id":"W1974913841","doi":"10.1161/circresaha.108.191171","title":"Bosentan Enhances Viral Load via Endothelin-1 Receptor Type-A–Mediated p38 Mitogen-Activated Protein Kinase Activation While Improving Cardiac Function During Coxsackievirus-Induced Myocarditis","year":2009,"lang":"en","type":"article","venue":"Circulation Research","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Bosentan; Viral Myocarditis; Myocarditis; Mitogen-activated protein kinase; Coxsackievirus; Endothelin receptor; Protein kinase A; Cardiac function curve; Receptor; Cell biology; Kinase; Biology; Medicine; Internal medicine; Immunology; Enterovirus; Virus; Heart failure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00123006,0.0002697014,0.0004222333,0.000698766,0.0008835819,0.0001479279,0.0001436663,0.0003813817,0.000536734],"category_scores_gemma":[0.001068916,0.0002675752,0.0001765542,0.001569557,0.0001695261,0.0007100534,0.00006726258,0.001231862,0.000582347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001137885,"about_ca_system_score_gemma":0.000558916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00067694,"about_ca_topic_score_gemma":0.000008669313,"domain_scores_codex":[0.9961042,0.0006837304,0.000500476,0.000684021,0.001217361,0.0008102084],"domain_scores_gemma":[0.9971916,0.0001370309,0.0001490967,0.0005822799,0.001709292,0.0002307197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001240067,0.000201329,0.002580697,0.00006879179,0.0001471747,0.000006788732,0.0001543359,0.00001682878,0.972082,0.00003160229,0.000186496,0.02328391],"study_design_scores_gemma":[0.001731304,0.001251057,0.1324055,0.000147354,0.00002885408,0.000008584984,0.0002128781,0.0006815763,0.861745,0.00008539433,0.001449494,0.0002529833],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942166,0.0003617862,0.0002747558,0.0006832078,0.0004908603,0.002154476,0.00001703985,0.0002323321,0.001568906],"genre_scores_gemma":[0.9971967,0.0001024296,0.00004542598,0.00005231653,0.0006065992,0.0001960935,0.0002994456,0.00004985198,0.001451185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1298248,"threshold_uncertainty_score":0.9999776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04860165747073657,"score_gpt":0.3323553367413513,"score_spread":0.2837536792706147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}