{"id":"W1974913841","doi":"10.1161/circresaha.108.191171","title":"Bosentan Enhances Viral Load via Endothelin-1 Receptor Type-A–Mediated p38 Mitogen-Activated Protein Kinase Activation While Improving Cardiac Function During Coxsackievirus-Induced Myocarditis","year":2009,"lang":"en","type":"article","venue":"Circulation Research","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Bosentan; Viral Myocarditis; Myocarditis; Mitogen-activated protein kinase; Coxsackievirus; Endothelin receptor; Protein kinase A; Cardiac function curve; Receptor; Cell biology; Kinase; Biology; Medicine; Internal medicine; Immunology; Enterovirus; Virus; Heart failure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002500532,0.0005121166,0.0004577996,0.0001463073,0.0001603853,0.0002812452,0.0001790049,0.0002863033,0.0008965122],"category_scores_gemma":[0.0001628289,0.0001042924,0.000262525,0.00009097296,0.0002973078,0.0003711072,0.0001118042,0.0007416366,0.0001931251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001663849,"about_ca_system_score_gemma":0.0001663121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002673913,"about_ca_topic_score_gemma":0.0004606513,"domain_scores_codex":[0.9998864,0.00002498497,0.000008954732,0.00001695531,0.00002490025,0.00003779925],"domain_scores_gemma":[0.9999222,0.00001079373,0.00002517473,0.000008619935,0.000007613722,0.00002562165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001024311,0.000172268,0.0001677761,0.00004671329,0.000008444656,0.00003308973,0.00001475403,0.00004758546,0.9957981,0.00003583351,0.00003620056,0.002614895],"study_design_scores_gemma":[0.0002828458,0.007748547,0.01700687,0.00001566998,0.00006509243,0.0003459228,0.00006011209,0.001709673,0.971314,0.00006694734,0.001373055,0.00001117232],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971576,0.001400275,0.0007950111,0.00006012111,0.0000539026,0.0000217388,0.00005365294,0.00002943106,0.0004283697],"genre_scores_gemma":[0.99656,0.0009100373,0.001194514,0.00007659355,0.00004736298,0.00005593714,0.0001775197,0.00001163903,0.0009663274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008965122,"threshold_uncertainty_score":0.002999127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04860165747073657,"score_gpt":0.3323553367413513,"score_spread":0.2837536792706147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}