{"id":"W1974914594","doi":"10.1016/j.bmcl.2011.05.131","title":"Synthesis and biological activities of 4-N-(anilinyl-n-[oxazolyl])-7-chloroquinolines (n= 3′ or 4′) against Plasmodium falciparum in in vitro models","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Malaria Research and Control","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Metropolitan University; Acadia University","funders":"Acadia University","keywords":"Plasmodium falciparum; Oxazole; Chemistry; In vitro; Cytotoxicity; Quinoline; Chemical synthesis; Potency; Stereochemistry; Biological activity; Combinatorial chemistry; Biochemistry; Malaria; Organic chemistry; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001591948,0.0003553322,0.0002457043,0.0001861171,0.0001516349,0.00009574823,0.0003450742,0.0001750073,0.001662228],"category_scores_gemma":[0.0001128936,0.0001634825,0.0002061807,0.0001216784,0.0001190917,0.0001420685,0.0001084447,0.0002165174,0.000433517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000205978,"about_ca_system_score_gemma":0.0002386739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001134802,"about_ca_topic_score_gemma":0.002048314,"domain_scores_codex":[0.9999256,0.00001858131,0.000008771213,0.00001084903,0.00001313246,0.00002303641],"domain_scores_gemma":[0.9999326,0.00001422239,0.00001850238,0.000007531991,0.00001168004,0.00001546576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005296245,0.00008207987,0.0001211037,0.0002038489,0.00001040406,0.0001204012,0.00002852485,0.0004482619,0.9918624,0.0001552006,0.0002046085,0.006233595],"study_design_scores_gemma":[0.00008871665,0.001348274,0.001762951,0.00001000117,0.00002231399,0.0001536227,0.00001133256,0.0003955341,0.9920645,0.00002596003,0.004107922,0.000008802956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9770049,0.007411023,0.005508878,0.000167351,0.0000890673,0.000177774,0.001533982,0.0001770589,0.007929921],"genre_scores_gemma":[0.9870761,0.002978992,0.00387615,0.00006313491,0.00002352529,0.00008196299,0.001329249,0.00001562924,0.004555159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001662228,"threshold_uncertainty_score":0.005560696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04989808208054915,"score_gpt":0.2556493654671326,"score_spread":0.2057512833865834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}