{"id":"W1974914594","doi":"10.1016/j.bmcl.2011.05.131","title":"Synthesis and biological activities of 4-N-(anilinyl-n-[oxazolyl])-7-chloroquinolines (n= 3′ or 4′) against Plasmodium falciparum in in vitro models","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Malaria Research and Control","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Metropolitan University; Acadia University","funders":"Acadia University","keywords":"Plasmodium falciparum; Oxazole; Chemistry; In vitro; Cytotoxicity; Quinoline; Chemical synthesis; Potency; Stereochemistry; Biological activity; Combinatorial chemistry; Biochemistry; Malaria; Organic chemistry; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004178552,0.0002946795,0.000758492,0.0001683324,0.00002905845,0.000007926984,0.0002299357,0.0002463562,0.0002815603],"category_scores_gemma":[0.0005517077,0.0002134582,0.0000800858,0.0002858982,0.0004495429,0.00009951455,0.0001014195,0.000479368,0.000002426513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001228628,"about_ca_system_score_gemma":0.0002049891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002123688,"about_ca_topic_score_gemma":0.00002209743,"domain_scores_codex":[0.997955,0.00006008282,0.0005360049,0.0004685676,0.0003911564,0.0005891764],"domain_scores_gemma":[0.9989839,0.000270604,0.0001242349,0.0003201993,0.00003993572,0.0002611341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005379889,0.0002472425,0.004363094,0.0003528316,0.00006245531,0.0004722367,0.0004870285,9.422263e-7,0.9868733,0.00001047989,0.00008020023,0.001670253],"study_design_scores_gemma":[0.002995568,0.0001208628,0.0132815,0.000336516,0.00004794392,0.000113864,0.001414028,0.0005993233,0.9807985,0.00003709127,0.00002642479,0.0002283325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943224,0.0004094476,0.00006755994,0.004010544,0.00004202801,0.000317159,0.00002329913,0.00003546838,0.0007720866],"genre_scores_gemma":[0.9983672,0.0003588778,0.0002609477,0.0007011738,0.0001559057,0.0000664039,0.00001486451,0.0000253006,0.00004935725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008918402,"threshold_uncertainty_score":0.8704571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04989808208054915,"score_gpt":0.2556493654671326,"score_spread":0.2057512833865834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}