{"id":"W1974917587","doi":"10.1021/tx200360m","title":"2,2′,3,3′,6,6′-Hexachlorobiphenyl (PCB 136) Is Enantioselectively Oxidized to Hydroxylated Metabolites by Rat Liver Microsomes","year":2011,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Environmental Health Sciences","keywords":"Metabolite; Microsome; Chemistry; Cytochrome P450; Metabolism; Enzyme; Enantiomer; Metabolic pathway; Biochemistry; Stereochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001556338,0.0003446316,0.0005347042,0.0002688839,0.0001403331,0.00005195736,0.001230777,0.0004530806,0.01591602],"category_scores_gemma":[0.001537652,0.0003104318,0.0001002428,0.001940781,0.001167911,0.0002995388,0.001052066,0.001003237,0.003619608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001054088,"about_ca_system_score_gemma":0.0001132431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004382723,"about_ca_topic_score_gemma":0.00006026968,"domain_scores_codex":[0.995183,0.0004940716,0.0005182066,0.001069429,0.0007435042,0.00199177],"domain_scores_gemma":[0.9979796,0.0005412754,0.00007747778,0.0006024201,0.00001845466,0.0007808013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002945203,0.0004719867,0.001340459,0.000005113783,0.00002693715,0.00005574109,0.001408478,1.858254e-7,0.9714869,0.00004580642,0.01593144,0.00893245],"study_design_scores_gemma":[0.0009613826,0.0002507061,0.008979308,0.00001387793,0.000008380448,0.0000316098,0.0000646437,0.00004976426,0.974261,0.001534998,0.0135027,0.0003416303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893961,0.0003798083,0.00003165604,0.001383323,0.0001153191,0.0007287942,0.00007703027,0.00008104939,0.007806914],"genre_scores_gemma":[0.9951556,0.0001200202,0.001630694,0.001105542,0.00004723115,0.00007106546,0.000003231766,0.00005868804,0.001807906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01229641,"threshold_uncertainty_score":0.9999348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06546596800771694,"score_gpt":0.3264725134793521,"score_spread":0.2610065454716352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}