{"id":"W1974920096","doi":"10.1158/1538-7445.am2013-lb-295","title":"Abstract LB-295: Detection of oncogenic kinase mutations in circulating plasma DNA and correlation with clinical benefit in the phase III GRID study of regorafenib <i>vs</i> placebo in TKI-refractory metastatic GIST.","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"Gastrointestinal Tumor Research and Treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital","funders":"","keywords":"Regorafenib; PDGFRA; GiST; Sunitinib; Cancer research; CD117; Sanger sequencing; Exon; Mutation; Stromal tumor; Medicine; Cancer; Internal medicine; Oncology; Biology; Pathology; Stromal cell; Colorectal cancer; CD34; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001292738,0.0003356251,0.0007112816,0.000240086,0.000120328,0.0004710794,0.0003458966,0.0003704585,0.001870694],"category_scores_gemma":[0.001304309,0.0002038094,0.0003096918,0.0002390036,0.0003701863,0.0002543477,0.0002268527,0.0007333055,0.0003551737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003776856,"about_ca_system_score_gemma":0.0003627116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003868314,"about_ca_topic_score_gemma":0.0005989944,"domain_scores_codex":[0.999447,0.0002925642,0.00004015898,0.0001014025,0.00008001395,0.00003871857],"domain_scores_gemma":[0.99899,0.0003180589,0.0003316803,0.00008456142,0.00006930796,0.0002064002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5953295,0.005575303,0.1969765,0.000525569,0.00128033,0.0004645235,0.0002192444,0.00173713,0.1196736,0.0001595681,0.002605021,0.07545382],"study_design_scores_gemma":[0.1584678,0.3307447,0.4520902,0.00004885994,0.00169303,0.002118201,0.000167584,0.005123954,0.04473177,0.0003878938,0.00436113,0.00006475497],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973717,0.0006328929,0.0003377274,0.00007181318,0.00001436683,0.0001505532,0.0006749167,0.00004579889,0.0007001398],"genre_scores_gemma":[0.997993,0.00009741986,0.0005146824,0.0001134467,0.00001700906,0.0001196347,0.0008793441,0.000006431833,0.0002591551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001870694,"threshold_uncertainty_score":0.006836712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.108706046004292,"score_gpt":0.4390632633332369,"score_spread":0.3303572173289449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}