{"id":"W1974994567","doi":"10.1042/bj20041112","title":"Thermodynamics of ligand binding by the yeast mRNA-capping enzyme reveals different modes of binding","year":2004,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Yeast; Enzyme; Thermodynamics; Chemistry; Ligand (biochemistry); Biochemistry; Physics; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002275455,0.0003716622,0.0004491876,0.0001455908,0.000227613,0.0003948249,0.0003634424,0.0002486337,0.001409968],"category_scores_gemma":[0.0004384928,0.0002036729,0.0001851608,0.0001763694,0.0002675017,0.0002255688,0.0001911519,0.0003767955,0.0003396826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005434456,"about_ca_system_score_gemma":0.0002489634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00335516,"about_ca_topic_score_gemma":0.003126865,"domain_scores_codex":[0.999791,0.00003439778,0.000008910332,0.00004765658,0.00008216529,0.00003590703],"domain_scores_gemma":[0.9998635,0.00006639217,0.00001634508,0.000006834539,0.0000261217,0.00002078895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003780468,0.000053139,0.005152661,0.0001894573,0.00005646931,0.0001402922,0.0001137727,0.01052103,0.9768486,0.0006508564,0.0001456947,0.005750027],"study_design_scores_gemma":[0.00001831983,0.0003226816,0.01579487,0.000009070937,0.00002823906,0.0001265367,0.0001196626,0.05021096,0.9316579,0.0003901726,0.001271268,0.00005041643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962258,0.0006067113,0.002155988,0.0000379323,0.000005980558,0.000008064516,0.0001369971,0.00005271745,0.0007698092],"genre_scores_gemma":[0.9990701,0.0001418112,0.0003852801,0.000007441182,0.000001886652,0.000005960643,0.0001431441,0.000007934055,0.0002364324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00335516,"threshold_uncertainty_score":0.00667125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01252091290836145,"score_gpt":0.2343686282989757,"score_spread":0.2218477153906143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}